氢气：在实体器官移植中的潜在应用。
Hydrogen: Potential Applications in Solid Organ Transplantation.
机构信息
Department of ICU, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Oxid Med Cell Longev. 2021 Nov 24;2021:6659310. doi: 10.1155/2021/6659310. eCollection 2021.
Abstract
Ischemia reperfusion injury (IRI) in organ transplantation has always been an important hotspot in organ protection. Hydrogen, as an antioxidant, has been shown to have anti-inflammatory, antioxidant, and antiapoptotic effects. In this paper, the protective effect of hydrogen against IRI in organ transplantation has been reviewed to provide clues for future clinical studies.
摘要
器官移植中的缺血再灌注损伤（IRI）一直是器官保护的重要热点。氢气作为一种抗氧化剂，具有抗炎、抗氧化和抗细胞凋亡作用。本文综述了氢气对器官移植中 IRI 的保护作用，为未来的临床研究提供线索。
相似文献
1
Hydrogen: Potential Applications in Solid Organ Transplantation.氢气：在实体器官移植中的潜在应用。
Oxid Med Cell Longev. 2021 Nov 24;2021:6659310. doi: 10.1155/2021/6659310. eCollection 2021.
2
Hydrogen, a potential safeguard for graft-versus-host disease and graft ischemia-reperfusion injury?氢气，移植物抗宿主病和移植物缺血再灌注损伤的潜在保护因素？
Clinics (Sao Paulo). 2016 Sep;71(9):544-9. doi: 10.6061/clinics/2016(09)10.
3
Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings.在实体器官移植中使用微量营养素和天然化合物防治缺血再灌注损伤：临床试验数据和临床前研究结果的经验教训。
Int J Mol Sci. 2021 Oct 1;22(19):10675. doi: 10.3390/ijms221910675.
4
Detrimental effects of prolonged warm renal ischaemia-reperfusion injury are abrogated by supplemental hydrogen sulphide: an analysis using real-time intravital microscopy and polymerase chain reaction.补充硫化氢可消除长时间温热肾缺血再灌注损伤的有害影响：实时活体显微镜和聚合酶链反应分析。
BJU Int. 2012 Dec;110(11 Pt C):E1218-27. doi: 10.1111/j.1464-410X.2012.11555.x. Epub 2012 Oct 9.
5
Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia-reperfusion injury by mitigating renal graft apoptosis and inflammation.补充的硫化氢通过减轻肾移植物细胞凋亡和炎症反应来保护移植肾的功能并延长长时间冷缺血再灌注损伤后受者的存活时间。
BJU Int. 2012 Dec;110(11 Pt C):E1187-95. doi: 10.1111/j.1464-410X.2012.11526.x. Epub 2012 Nov 16.
6
Ischemic conditioning in solid organ transplantation: is it worth giving your right arm for?在实体器官移植中应用缺血预处理：值得付出右臂的代价吗？
Curr Opin Nephrol Hypertens. 2017 Nov;26(6):467-476. doi: 10.1097/MNH.0000000000000367.
7
Medical Application of Hydrogen in Hematological Diseases.氢气在血液系统疾病中的医学应用
Oxid Med Cell Longev. 2019 Nov 28;2019:3917393. doi: 10.1155/2019/3917393. eCollection 2019.
8
Anti-inflammatory approaches to the prevention of ischemia/reperfusion injury in solid organ transplantation.实体器官移植中预防缺血/再灌注损伤的抗炎方法。
Curr Opin Investig Drugs. 2005 May;6(5):508-12.
9
New Insights in Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury 2.0: An Updated Overview.缺血再灌注损伤的分子机制和病理生理学的新见解 2.0：更新概述。
Int J Mol Sci. 2020 Dec 22;22(1):28. doi: 10.3390/ijms22010028.
10
Extrapolating novel techniques utilised in solid organ transplantation to the microsurgical and vascularised composite allograft arena.将实体器官移植中使用的新技术外推到显微外科和血管化复合异体移植领域。
J Plast Reconstr Aesthet Surg. 2019 Jan;72(1):20-22. doi: 10.1016/j.bjps.2018.10.039.
引用本文的文献
1
Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review.分子氢：对抗氧化应激的机制及其在牙周炎中的应用：综述
Medicine (Baltimore). 2025 Mar 7;104(10):e41800. doi: 10.1097/MD.0000000000041800.
2
Hydrogen in Transplantation: Potential Applications and Therapeutic Implications.氢在移植中的潜在应用及治疗意义
Biomedicines. 2024 Jan 6;12(1):118. doi: 10.3390/biomedicines12010118.
本文引用的文献
1
Luminal preloading with hydrogen-rich saline ameliorates ischemia-reperfusion injury following intestinal transplantation in rats.富氢盐水预灌流减轻大鼠肠移植后缺血再灌注损伤。
Pediatr Transplant. 2020 Nov;24(7):e13848. doi: 10.1111/petr.13848. Epub 2020 Sep 30.
2
Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model.富氢液在犬肺移植模型中的保护作用。
Ann Thorac Surg. 2021 Jan;111(1):246-252. doi: 10.1016/j.athoracsur.2020.05.076. Epub 2020 Jul 8.
3
Early graft function and intrarenal resistant index after kidney transplantation using Biolasol-A new solid organ preservation fluid.使用 Biolasol-新型器官保存液进行肾移植后的早期移植物功能和肾内阻力指数。
Artif Organs. 2020 Nov;44(11):1211-1219. doi: 10.1111/aor.13742. Epub 2020 Jul 8.
4
Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation.富氢溶液在大鼠肺移植冷缺血期间的保护作用。
J Thorac Cardiovasc Surg. 2020 May;159(5):2110-2118. doi: 10.1016/j.jtcvs.2019.09.175. Epub 2019 Oct 30.
5
Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.含溶解氢气的器官保存液从氢气吸收合金罐可改善小型猪移植缺血肾脏的功能。
PLoS One. 2019 Oct 1;14(10):e0222863. doi: 10.1371/journal.pone.0222863. eCollection 2019.
6
Machine Perfusion for Abdominal Organ Preservation: A Systematic Review of Kidney and Liver Human Grafts.用于腹部器官保存的机器灌注：对人肾和肝移植的系统评价
J Clin Med. 2019 Aug 15;8(8):1221. doi: 10.3390/jcm8081221.
7
Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death.氢气吸入对心脏死亡供体大鼠在热缺血期对肺缺血再灌注损伤的保护作用。
Microvasc Res. 2019 Sep;125:103885. doi: 10.1016/j.mvr.2019.103885. Epub 2019 Jun 5.
8
A new organ preservation solution for static cold storage of the liver. Amniotic fluid.一种用于肝脏静态冷藏的新型器官保存液。羊水。
Acta Cir Bras. 2019 Apr 29;34(4):e201900402. doi: 10.1590/s0102-865020190040000002.
9
Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.富氢溶液减轻大鼠肝移植中的冷缺血-再灌注损伤。
BMC Gastroenterol. 2019 Feb 8;19(1):25. doi: 10.1186/s12876-019-0939-7.
10
Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.冷存储后进行氢气冲洗：一种新的针对肝移植物缺血/再灌注损伤的末缺血期体外处理方法。
Liver Transpl. 2018 Nov;24(11):1589-1602. doi: 10.1002/lt.25326.
Zotero 插件