Husted Thomas L, Lentsch Alex B
The Laboratory of Trauma, Sepsis & Inflammation Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0558, USA.
Curr Opin Investig Drugs. 2005 May;6(5):508-12.
Ischemia/reperfusion injury can contribute to organ dysfunction and failure after transplantation. Reperfusion injury is often associated with an acute inflammatory response, involving transcriptional activation and expression of pro-inflammatory mediators, and culminates in the recruitment of leukocytes to the post-ischemic tissue. In this concise review, we will address the current knowledge of acute inflammation relevant to ischemia/reperfusion injury and solid organ transplantation, and discuss current treatment options that may have application in this regard, as well as new areas that may be ripe for therapeutic drug design.
缺血/再灌注损伤可导致移植后器官功能障碍和衰竭。再灌注损伤通常与急性炎症反应相关，涉及促炎介质的转录激活和表达，并最终导致白细胞募集到缺血后组织。在这篇简要综述中，我们将阐述与缺血/再灌注损伤及实体器官移植相关的急性炎症的现有知识，并讨论目前可能适用于这方面的治疗选择，以及可能适合治疗药物设计的新领域。
