Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed to be University), New Delhi, India.
Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed to be University), New Delhi, India.
Eur J Med Chem. 2019 Sep 15;178:687-704. doi: 10.1016/j.ejmech.2019.06.010. Epub 2019 Jun 13.
Free radicals generated due to exposure of radiation, environmental pollutants and as by-products of metabolised drugs. These free radicals are antagonized by molecules which are antioxidant in nature. Antioxidants are the substances which inhibit oxidation. They are moreover acknowledged as "free radical scavengers" as they form minor reactive species via radicals. Based on origin, they are categorised into two types: exogenous and endogenous antioxidants. An Antioxidant reduces the occurrence of different disorders like: aging, cancer, diabetes, inflammation, liver disease, cardiovascular disease, cataract and nephrotoxicity and neurodegenerative disorders. Dietary antioxidants are thought to have potential capacities to avert oxidative anxiety induced diseases. This review figures the various researches on pharmacological activity of natural along with synthetic antioxidant molecules.
自由基是由于辐射暴露、环境污染物和代谢药物的副产物产生的。这些自由基被具有抗氧化性质的分子所拮抗。抗氧化剂是抑制氧化的物质。它们被认为是“自由基清除剂”，因为它们通过自由基形成较小的反应性物质。根据来源，它们分为两类：外源性和内源性抗氧化剂。抗氧化剂可减少不同疾病的发生，如衰老、癌症、糖尿病、炎症、肝病、心血管疾病、白内障和肾毒性以及神经退行性疾病。人们认为膳食抗氧化剂具有潜在的能力来预防氧化应激引起的疾病。这篇综述阐述了天然和合成抗氧化分子的药理学活性的各种研究。
