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以全身瘙痒和视力逐渐丧失为首发症状的急性HIV感染:COVID-19大流行期间的管理挑战

Generalized Pruritus and Gradual Loss of Vision as the Presenting Complaints of Acute HIV Infection: Management Challenges during COVID-19 Pandemic.

作者信息

Paul Shrebash, Rahman S M Mahbubur, Rahman Rajibur, Rahman Mahbubur, Uddin Ahmed Quazi Mamtaz, Alam Rafiqul, Chowdhury Fazle Rabbi

机构信息

Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand.

出版信息

Case Rep Infect Dis. 2021 Dec 1;2021:6436936. doi: 10.1155/2021/6436936. eCollection 2021.

Abstract

BACKGROUND

Although the prevalence of HIV is low in Bangladesh, there is a potential for an increased number of cases. This is because of high cross-border mobility (India and Myanmar) of people and increased injection drug abusers amongst youth in the cities and rural areas, HIV can present in many ways, from asymptomatic to advanced disease, including various atypical (generalized itching) and advanced (loss of vision) manifestations. A high degree of suspicion is required to diagnose HIV in a country like Bangladesh. Early diagnosis and prompt treatment are essential to have a better outcome.

METHODS

Here, we report two thought-provoking cases where patients were suffering from generalized itchy lesions (pruritic papular eruption) throughout the body for a long time and gradual loss of vision in another case.

RESULTS

Due to lack of suspicion, initially, HIV screening was not done. Both patients visited several health centres, but no diagnosis was made. Moreover, COVID-19 pandemic worsens the situation. Finally, they were diagnosed with HIV; unfortunately, one of them lost her vision due to CMV retinitis and another patient died of other complications.

CONCLUSION

Ongoing COVID-19 pandemic put many challenges to ensure optimum care, especially for patients with long-sufferings like HIV. Clinicians have to have a very high degree of suspicion while dealing with patients presented with rare manifestations, particularly in a low endemic clinical setting.

摘要

背景

尽管孟加拉国的艾滋病毒感染率较低,但病例数仍有可能增加。这是因为人员的跨境流动性较高(印度和缅甸),以及城市和农村地区青年中注射吸毒者人数增加。艾滋病毒可以有多种表现形式,从无症状到晚期疾病,包括各种非典型(全身瘙痒)和晚期(视力丧失)表现。在孟加拉国这样的国家,诊断艾滋病毒需要高度怀疑。早期诊断和及时治疗对于取得更好的结果至关重要。

方法

在此,我们报告两例发人深省的病例,其中一例患者长期全身出现广泛性瘙痒性皮疹,另一例逐渐视力丧失。

结果

由于缺乏怀疑,最初未进行艾滋病毒筛查。两名患者都去过几家医疗中心,但均未确诊。此外,新冠疫情使情况恶化。最终,他们被诊断出感染艾滋病毒;不幸的是,其中一人因巨细胞病毒性视网膜炎失明,另一人死于其他并发症。

结论

持续的新冠疫情给确保最佳护理带来了诸多挑战,尤其是对于像艾滋病毒患者这样长期患病的人。临床医生在处理表现出罕见症状的患者时,必须高度怀疑,特别是在低流行的临床环境中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1403/8633852/fa6120c70913/CRIID2021-6436936.001.jpg

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