School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, United States.
Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX, United States.
Front Cell Infect Microbiol. 2021 Nov 17;11:789919. doi: 10.3389/fcimb.2021.789919. eCollection 2021.
Periodontitis disproportionately affects different racial and ethnic populations. In this study, we used qPCR to determine and compare oral microbial profiles in dental plaque samples from 191 periodontitis patients of different ethnic/racial backgrounds. We also obtained the periodontal parameters of these patients retrospectively using axiUm and performed statistical analysis using SAS 9.4. We found that in this patient cohort, neighborhood median incomes were significantly higher among Caucasians Americans (CAs) than among African Americans (AAs) and Hispanic Americans (HAs). Levels of total bacteria and , a keystone periodontal pathogen, were not evenly distributed among the three groups. We confirmed our previous findings that reduces virulence potential and likely serves as a beneficial bacterium. We also showed the ratio of to to be significantly higher in CAs than in HAs and AAs. Our results suggest that higher levels of and lower ratios of to may contribute to periodontal health disparities.
牙周炎在不同的种族和民族中发病率不均。在这项研究中，我们使用 qPCR 来确定和比较来自 191 名不同种族/民族背景的牙周炎患者的牙菌斑样本中的口腔微生物谱。我们还使用 axiUm 回顾性地获得这些患者的牙周参数，并使用 SAS 9.4 进行统计分析。我们发现，在这个患者队列中，白种美国人（CAs）的社区中位数收入明显高于非裔美国人（AAs）和西班牙裔美国人（HAs）。三种人群的总细菌水平和一种关键的牙周病原体水平分布不均。我们证实了我们之前的发现，即 减少了 毒力潜能，可能是一种有益的细菌。我们还表明，CAs 中 与 的比例明显高于 HAs 和 AAs。我们的结果表明，更高水平的 和更低的 与 的比例可能导致牙周健康的差异。
