Department of Periodontics, Guiyang Stomatological Hospital, Guiyang, Guizhou, China.
School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
PLoS One. 2024 Sep 27;19(9):e0310243. doi: 10.1371/journal.pone.0310243. eCollection 2024.
Whether there is an association between serum uric acid level (sUA) and periodontitis remains unclear. The aim of this study was to investigate the association between moderate/severe periodontitis and sUA in US adults.
A total of 3398 participants were included in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014. The independent variable was sUA and the dependent variable was periodontitis. SUA for continuous variables, periodontitis as classification variables. Covariate including social demographic variables, life style, systemic diseases, etc. Multiple linear regression models were used to investigate the distribution of differences in covariates between different independent groups. To investigate the association between serum uric acid levels and moderate/severe periodontitis, three models were used (Model 1: unadjusted model; Model 2: adjusted for age, sex, and race/ethnicity; Model 3: adjusted for age, sex, race/ethnicity, education, household income/poverty ratio, smoking behavior, alcohol consumption, dental floss frequency, obesity, hypertension, diabetes, high cholesterol, hyperlipidemia, and sleep disorders).
Among the 3398 patients, 42.5% had moderate/severe periodontitis. Multivariate logistic regression analysis showed that sUA was significantly associated with moderate/severe periodontitis (OR = 1.10, 95%CI: (1.03, 1.16), P = 0.0020) after adjusting for potential confounding factors. In addition, it may vary by race/ethnicity and gender. The association between sUA levels and the prevalence ofperiodontitis was U-shaped in women and non-Hispanic blacks.
sUA level is associated with moderate to severe periodontitis. However, the association between sUA levels and the occurrence of periodontitis in women and non-Hispanic blacks followed a U-shaped curve.
sUA may directly or indirectly contribute to the global burden of periodontal disease, but there is little evidence that sUA is directly related to periodontitis.This study further supports that high uric acid levels are closely related to periodontitis and may contribute to the control of periodontitis. It also provides new insights into whether it can be used as an indicator to assess the risk or progression of periodontitis. More studies are needed to confirm the relationship between sUA and periodontitis.
血尿酸水平（sUA）与牙周炎之间是否存在关联尚不清楚。本研究旨在调查美国成年人中中重度牙周炎与 sUA 之间的关系。
共纳入 2009 年至 2014 年全国健康与营养调查（NHANES）中的 3398 名参与者。自变量为 sUA，因变量为牙周炎。SUA 为连续变量，牙周炎为分类变量。协变量包括社会人口统计学变量、生活方式、系统疾病等。采用多元线性回归模型来研究不同独立组之间协变量分布差异。为了研究血清尿酸水平与中重度牙周炎之间的关系，使用了三个模型（模型 1：未调整模型；模型 2：调整年龄、性别和种族/民族；模型 3：调整年龄、性别、种族/民族、教育程度、家庭收入/贫困率、吸烟行为、饮酒、牙线使用频率、肥胖、高血压、糖尿病、高胆固醇、高血脂、睡眠障碍）。
在 3398 名患者中，42.5%患有中重度牙周炎。多变量逻辑回归分析显示，在校正潜在混杂因素后，sUA 与中重度牙周炎显著相关（OR=1.10，95%CI：（1.03，1.16），P=0.0020）。此外，这种关联可能因种族/民族和性别而异。在女性和非西班牙裔黑人中，sUA 水平与牙周炎患病率之间的关系呈 U 型。
sUA 水平与中重度牙周炎有关。然而，女性和非西班牙裔黑人中 sUA 水平与牙周炎发生之间的关系呈 U 型。
sUA 可能直接或间接导致牙周病的全球负担，但目前几乎没有证据表明 sUA 与牙周炎直接相关。本研究进一步支持高尿酸水平与牙周炎密切相关，并可能有助于控制牙周炎。这也为尿酸水平是否可以用作评估牙周炎风险或进展的指标提供了新的见解。需要更多的研究来证实 sUA 与牙周炎之间的关系。
