Lu Mei-Chun, Chen I-Ju, Hsu Le-Tien, Chen Ying-Jen, Tsou Meng-Ting, Tung Tao-Hsin, Chen Jau-Yuan
Department of Family Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City, Taiwan.
Department of Gynecology and Obstetrics, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Front Med (Lausanne). 2021 Nov 16;8:748037. doi: 10.3389/fmed.2021.748037. eCollection 2021.
This study aimed to quantify the proportion of participants with chronic kidney disease (CKD) and associated metabolic risk factors in a middle-aged and elderly population in Guishan District, Taoyuan City, Taiwan. This cross-sectional study enrolled residents aged 50-90 years living in one community. All participants received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples collected for laboratory testing. CKD was defined as the presence of kidney damage (urine albumin-creatinine ratio ≥30 mg/g) or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m. Multiple logistic regression models were used to evaluate the risk factors associated with CKD. A total of 400 participants were enrolled. The overall proportion of participants with CKD was 20.5% (95% confidence interval [CI]: 16.54-24.46%). The proportions of participants with CKD among those aged 50-64, 65-74, and 75 years and over were 17.7, 18.8, and 35.7%, respectively ( = 0.01). Multiple logistic regression model revealed that elevated blood pressure (odds ratio [OR] = 2.23, 95% CI: 1.16-4.30), hyperglycemia (OR = 2.87, 95% CI: 1.64-5.00), hyperuricemia (OR = 1.38, 95% CI: 1.14-1.69), and metabolic syndrome (OR = 2.30, 95% CI: 1.31-4.06) were significantly associated with CKD. The prevalence of CKD in the study population was high. Hypertension, hyperglycemia, hyperuricemia, and metabolic syndrome are significantly associated with CKD in a middle-aged and elderly population in Taiwan.
本研究旨在量化台湾桃园市龟山区中老年人群中慢性肾脏病（CKD）患者及相关代谢危险因素的比例。这项横断面研究纳入了居住在一个社区的50 - 90岁居民。所有参与者均接受了标准化的个人访谈，包括结构化问卷、人体测量以及采集血样进行实验室检测。CKD的定义为存在肾损伤（尿白蛋白 - 肌酐比值≥30 mg/g）或估算肾小球滤过率（eGFR）<60 mL/min/1.73 m²。采用多元逻辑回归模型评估与CKD相关的危险因素。共纳入400名参与者。CKD参与者的总体比例为20.5%（95%置信区间[CI]：16.54 - 24.46%）。50 - 64岁、65 - 74岁以及75岁及以上参与者中CKD的比例分别为17.7%、18.8%和35.7%（P = 0.01）。多元逻辑回归模型显示，血压升高（比值比[OR]=2.23，95% CI：1.16 - 4.30）、高血糖（OR = 2.87，95% CI：1.64 - 5.00）、高尿酸血症（OR = 1.38，95% CI：1.14 - 1.69）以及代谢综合征（OR = 2.30，95% CI：1.31 - 4.06）与CKD显著相关。研究人群中CKD的患病率较高。在台湾的中老年人群中，高血压、高血糖、高尿酸血症和代谢综合征与CKD显著相关。
