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一种配备粘性吸盘夹具的靶向治疗给药针。

: A Sticky Suction Cup Gripper Equipped Needle for Targeted Therapeutics Delivery.

作者信息

Joymungul Kieran, Mitros Zisos, da Cruz Lyndon, Bergeles Christos, Sadati S M Hadi

机构信息

School of Biomedical Engineering and Imaging Sciences Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, United Kingdom.

出版信息

Front Robot AI. 2021 Nov 19;8:752290. doi: 10.3389/frobt.2021.752290. eCollection 2021.

Abstract

This paper presents a multi-purpose gripping and incision tool-set to reduce the number of required manipulators for targeted therapeutics delivery in Minimally Invasive Surgery. We have recently proposed the use of multi-arm Concentric Tube Robots (CTR) consisting of an incision, a camera, and a gripper manipulator for deep orbital interventions, with a focus on Optic Nerve Sheath Fenestration (ONSF). The proposed prototype in this research, called , is a needle equipped with a sticky suction cup gripper capable of performing both gripping of target tissue and incision tasks in the optic nerve area by exploiting the multi-tube arrangement of a CTR for actuation of the different tool-set units. As a result, there will be no need for an independent gripper arm for an incision task. The CTR innermost tube is equipped with a needle, providing the pathway for drug delivery, and the immediate outer tube is attached to the suction cup, providing the suction pathway. Based on experiments on various materials, we observed that adding a sticky surface with bio-inspired grooves to a normal suction cup gripper has many advantages such as, 1) enhanced adhesion through material stickiness and by air-tightening the contact surface, 2) maintained adhesion despite internal pressure variations, e.g. due to the needle motion, and 3) sliding resistance. Simple Finite Element and theoretical modeling frameworks are proposed, based on which a miniature tool-set is designed to achieve the required gripping forces during ONSF. The final designs were successfully tested for accessing the optic nerve of a realistic eye phantom in a skull eye orbit, robust gripping and incision on units of a plastic bubble wrap sample, and manipulating different tissue types of porcine eye samples.

摘要

本文提出了一种多用途抓持和切割工具集,以减少微创手术中靶向治疗输送所需的操纵器数量。我们最近提出使用多臂同心管机器人(CTR),它由一个切割器、一个摄像头和一个抓持操纵器组成,用于深部眼眶干预,重点是视神经鞘开窗术(ONSF)。本研究中提出的原型,称为 ,是一种配备粘性吸盘抓持器的针,通过利用CTR的多管排列来驱动不同的工具集单元,能够在视神经区域执行目标组织的抓持和切割任务。因此,无需为切割任务配备独立的抓持臂。CTR的最内管配备有针,提供药物输送路径,紧邻的外管连接到吸盘,提供抽吸路径。基于对各种材料的实验,我们观察到在普通吸盘抓持器上添加具有生物启发凹槽的粘性表面有许多优点,例如,1)通过材料粘性和气密接触表面增强附着力,2)尽管内部压力变化(例如由于针的运动)仍保持附着力,3)滑动阻力。提出了简单的有限元和理论建模框架,在此基础上设计了一个微型工具集,以在ONSF期间实现所需的抓持力。最终设计在模拟的颅骨眼眶中的真实眼球模型上成功测试了对视神经的进入、对塑料气泡包装样品单元的稳健抓持和切割以及对猪眼样品不同组织类型的操作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2005/8640244/f2441b61707b/frobt-08-752290-g001.jpg

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