用于正电子断层扫描的氧-15丁醇的制备
Preparation of oxygen-15 butanol for positron tomography.
作者信息
Berridge M S, Franceschini M P, Tewson T J, Gould K L
出版信息
J Nucl Med. 1986 Jun;27(6):834-7.
PMID:3486964
Abstract
Butanol was labeled with 15O using the reaction of tri-n-butyl borane with oxygen gas. The carrier-added synthesis and purification was accomplished in 4 min from the end of bombardment. The efficiency of radiolabel incorporation was 50%. The procedure described will produce [15O]butanol in an amount and quality sufficient for positron tomographic use. This compound is immediately useful for blood flow measurement based upon previous validation of butanol labeled with other radionuclides for that purpose.
摘要
使用三正丁基硼烷与氧气的反应，用(^{15}O)标记丁醇。从轰击结束起，4分钟内完成载体添加合成及纯化。放射性标记掺入效率为50%。所述程序将产生数量和质量足以用于正电子断层扫描的([^{15}O])丁醇。基于先前用其他放射性核素标记丁醇用于该目的的验证，该化合物可立即用于血流量测量。
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