Muzik O, Beanlands R S, Hutchins G D, Mangner T J, Nguyen N, Schwaiger M
Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor 48109-0028.
J Nucl Med. 1993 Jan;34(1):83-91.
Positron emission tomography has been shown to provide quantitative estimates of myocardial blood flow using 13N-ammonia and 15O-water. In a validation study, myocardial blood flow was noninvasively determined in 11 open-chest anesthetized dogs using dynamic positron emission tomography. The radiopharmaceuticals 13N-ammonia and 15O-water were intravenously administered and measurements were carried out at rest and following pharmacological vasodilation to assess blood flow over a range from 53 to 580 ml/100 g/min. Quantification of blood flow based on tracer kinetic modeling of 13N-ammonia data correlated closely with myocardial blood flow determined by microspheres (y = 0.944 x +7.22, r = 0.986) and with the 15O-water injection technique y = 1.054 x -15.8 (r = 0.99). The use of 13N-ammonia with positron emission tomography enables the accurate quantification of myocardial blood flow. Using this technique, uncomplicated study protocols simplify the measurement procedures while providing excellent qualitative and quantitative information.
正电子发射断层扫描已被证明可使用13N-氨和15O-水对心肌血流量进行定量估计。在一项验证研究中，使用动态正电子发射断层扫描对11只开胸麻醉犬的心肌血流量进行了无创测定。静脉注射放射性药物13N-氨和15O-水，并在静息状态和药物性血管舒张后进行测量，以评估53至580 ml/100 g/min范围内的血流量。基于13N-氨数据的示踪剂动力学模型对血流量的定量与微球测定的心肌血流量密切相关（y = 0.944 x +7.22，r = 0.986），与15O-水注射技术也密切相关（y = 1.054 x -15.8，r = 0.99）。将13N-氨与正电子发射断层扫描结合使用能够准确量化心肌血流量。使用该技术，简单的研究方案简化了测量程序，同时提供了出色的定性和定量信息。
