Durkin Tyler J, Barua Baishali, Savagatrup Suchol
Department of Chemical and Environmental Engineering, University of Arizona, 1133 East James E. Rogers Way, Tucson, Arizona 85721, United States.
ACS Omega. 2021 Nov 18;6(47):31390-31395. doi: 10.1021/acsomega.1c04788. eCollection 2021 Nov 30.
Sepsis is a major cause of mortality among hospitalized patients worldwide. Rapid diagnosis is critical as early treatments have been demonstrated to improve survival. Despite the importance of early detection, current technologies and clinical methods are often insufficient due to their lack of the necessary speed, selectivity, or sensitivity. The development of rapid sensing platforms that target sepsis-related biomarkers could significantly improve the outcomes of patients. This Mini-Review focuses on the recent advances in rapid diagnosis of soluble biomarkers in blood with the emphasis on different configurations of point-of-care (POC) instruments. Specifically, it first describes the commonly targeted biomarkers and the mechanisms by which they are detected. Then, it highlights the recently developed sensors that aim to reduce the total time of diagnosis without sacrificing selectivity and limit of detection. These sensors are categorized based on their distinct sensing and transduction mechanisms. Finally, it concludes with a brief outlook over future developments of multiplexed sensors.
脓毒症是全球住院患者死亡的主要原因。快速诊断至关重要，因为早期治疗已被证明可提高生存率。尽管早期检测很重要，但由于当前技术和临床方法缺乏必要的速度、选择性或灵敏度，往往并不充分。针对脓毒症相关生物标志物的快速传感平台的开发可显著改善患者的治疗结果。本综述聚焦于血液中可溶性生物标志物快速诊断的最新进展，重点关注即时检测（POC）仪器的不同配置。具体而言，它首先描述了常见的目标生物标志物及其检测机制。然后，它强调了最近开发的旨在在不牺牲选择性和检测限的情况下减少诊断总时间的传感器。这些传感器根据其独特的传感和转导机制进行分类。最后，它对多路复用传感器的未来发展进行了简要展望。
