Research Scholar, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India-400076.
Analyst. 2018 Mar 12;143(6):1326-1348. doi: 10.1039/c7an01771e.
The early diagnosis and monitoring of the progress of cancers are limited due to the lack of adequate screening tools. Ultrasensitive and precise point-of-care cancer diagnostic tools are required for the early detection and screening of cancer biomarkers at the bedside with accuracy and specificity of diagnosis. Recent advances in nano- and microfabrication based technologies integrated with different sensing platforms are accelerating the development of rapid, low-cost and reliable point-of-care cancer diagnostic devices. These technologies allow low volumes of reagents and samples, reduced analysis time, are disposable and portable, and provide ultrasensitive multiplexed analysis to improve diagnostic and prognostic evaluations. Networking for communicating and transferring the results through wireless networks provides additional opportunities for remote telemedicine-based diagnosis and planning of treatment regimens, even in semi-urban and rural areas. This review focuses on recent advances in point-of-care cancer diagnostics for efficient treatment along with the key challenges, opportunities and future scope of these technologies for clinical translation.
由于缺乏足够的筛查工具，癌症的早期诊断和监测受到限制。需要超灵敏和精确的即时护理癌症诊断工具，以便在床边以准确性和特异性对癌症生物标志物进行早期检测和筛查。基于纳米和微加工技术的最新进展与不同的传感平台相结合，正在加速快速、低成本和可靠的即时护理癌症诊断设备的发展。这些技术允许使用少量的试剂和样本，减少分析时间，可一次性使用且便于携带，并提供超灵敏的多重分析，以改善诊断和预后评估。通过无线网络进行通信和传输结果的联网为远程远程医疗诊断和治疗方案规划提供了额外的机会，即使在半城市和农村地区也是如此。这篇综述重点介绍了即时护理癌症诊断方面的最新进展，以实现有效的治疗，同时还讨论了这些技术在临床转化方面的关键挑战、机遇和未来前景。
