Group for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Biosensors (Basel). 2022 Dec 23;13(1):17. doi: 10.3390/bios13010017.
Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfaces are suspected to be a cause of these limitations. Here, we first present an updated overview of the current state of use of capacitive biosensors in a medical context. Then, we summarize the encountered strategies for the fabrication of capacitive biosensing surfaces. Finally, we describe the characteristics which govern the performance of the sensing surfaces, along with recent developments that were suggested to overcome their main current limitations.
尽管生物传感器具有高灵敏度和适用于小型化的特点，但由于其检测性能缺乏重现性和特异性，它们在临床应用中仍然受到限制。传感表面的设计和制备被怀疑是造成这些限制的原因。在这里，我们首先对当前在医学背景下使用电容式生物传感器的情况进行了最新的综述。然后，我们总结了用于制造电容式生物传感表面的遇到的策略。最后，我们描述了控制传感表面性能的特性，并介绍了为克服其当前主要限制而提出的最新进展。
