Department of Chemical and Civil Engineering, University of Kurdistan, 66177-15175 Sanandaj, Iran.
Biosens Bioelectron. 2017 Dec 15;98:494-506. doi: 10.1016/j.bios.2017.07.024. Epub 2017 Jul 11.
Advances in miniaturization, nanotechnology, and microfluidics, along with developments in cloud-connected point-of-care (POC) diagnostics technologies are pushing the frontiers of POC devices toward low-cost, user-friendly, and enhanced sensitivity molecular-level diagnostics. The combination of various bio-sensing platforms within smartphone-integrated electronic readers provides accurate on-site and on-time diagnostics based on various types of chemical and biological targets. Further, 3D printing technology shows a huge potential toward fabrication and improving the performance of POC devices. Integration of skin-like flexible sensors with wireless communication technology creates a unique opportunity for continuous, real-time monitoring of patients for both preventative healthcare and during disease outbreaks. Here, we review recent developments and advances in POC technologies and describe how these advances enhance the performance of POC platforms. Also, this review describes challenges, directions, and future trends on application of emerging technologies in POC diagnostics.
微型化、纳米技术和微流控技术的进步，以及与云连接的即时诊断 (POC) 诊断技术的发展，正在推动 POC 设备向低成本、用户友好和增强灵敏度的分子水平诊断方向发展。智能手机集成电子读取器内的各种生物传感平台的组合，为各种类型的化学和生物靶标提供了准确的现场和实时诊断。此外，3D 打印技术在制造和改善 POC 设备性能方面显示出巨大的潜力。皮肤般柔软的传感器与无线通信技术的集成，为患者的连续、实时监测提供了独特的机会，无论是在预防保健期间还是在疾病爆发期间。在这里，我们回顾了 POC 技术的最新发展和进步，并描述了这些进步如何增强 POC 平台的性能。此外，本综述还描述了新兴技术在 POC 诊断中的应用所面临的挑战、方向和未来趋势。
