Firth Anton, Prathapan Praveen
New Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Curr Res Pharmacol Drug Discov. 2021;2:100011. doi: 10.1016/j.crphar.2020.100011. Epub 2020 Dec 11.
There are currently no emergency treatments for pandemics, yet drug repositioning has emerged as the foremost treatment development strategy for COVID-19, with an aim to identify successful antiviral therapeutics from safe, non-antiviral candidates. These therapeutics include antibiotics such as azithromycin and the antiparasitic nitazoxanide, both of which exhibit antiviral activity. Broad-spectrum therapeutics (BSTs) are a class of antimicrobials active against multiple pathogen types. Establishment of a developmental framework for BSTs will markedly improve global preparedness for future health emergencies.
目前尚无针对大流行的紧急治疗方法，然而药物重新定位已成为COVID-19最重要的治疗开发策略，其目的是从安全的非抗病毒候选药物中确定成功的抗病毒疗法。这些疗法包括阿奇霉素等抗生素和抗寄生虫药硝唑尼特，二者均具有抗病毒活性。广谱疗法（BSTs）是一类对多种病原体具有活性的抗菌药物。建立BSTs的开发框架将显著提高全球对未来卫生紧急情况的防范能力。
