Eckert R, Repke H
Methods Find Exp Clin Pharmacol. 1986 Mar;8(3):183-7.
Histamine induces the T-cell dependent production of both suppressive and enhancing factor via its interaction with H2-receptors. This could be shown by the transfer of cells or crude lymphokine preparations after in vitro histamine treatment into recipient mice, which were characterized with respect to their humoral immune response. The effective histamine concentrations differed remarkably among different mouse strains which indicates a complex regulatory network. The combined in vitro/in vivo approach as performed in these experiments leads to the conclusion that histamine may act as a suppressive as well as an enhancing immunomodulator on the humoral immune response in vivo.
组胺通过与H2受体相互作用诱导T细胞依赖性产生抑制因子和增强因子。这可以通过将体外组胺处理后的细胞或粗制淋巴因子制剂转移到受体小鼠中来证明，这些受体小鼠的体液免疫反应得到了表征。不同小鼠品系之间有效的组胺浓度差异显著，这表明存在一个复杂的调节网络。这些实验中采用的体外/体内联合方法得出结论，组胺在体内对体液免疫反应可能既起抑制性免疫调节剂的作用，也起增强性免疫调节剂的作用。
