Tomilets V A
Biull Eksp Biol Med. 1982 Jun;93(6):79-80.
A study was made of histamine action on different lymphocyte subpopulations of the mouse spleen during sensitization with ovalbumin. Histamine was shown to exert a regulatory action on proliferation of but rapidly depositing fraction of spleen lymphocytes, which corresponds with suppressor T lymphocytes. The line and intensity of histamine action depended on the time of sensitization. In the initial period histamine reduced the proliferation rate, while on day 3 it stimulated the incorporation of labeled thymidine. The action of histamine was realized through the H2-histamine receptors and was mediated by the increased concentration of cAMP in the lymphocytes.
对卵清蛋白致敏过程中小鼠脾脏不同淋巴细胞亚群的组胺作用进行了研究。结果表明，组胺对脾脏淋巴细胞中快速沉积部分的增殖具有调节作用，这部分淋巴细胞与抑制性T淋巴细胞相对应。组胺作用的方向和强度取决于致敏时间。在致敏初期，组胺降低了增殖率，而在第3天它刺激了标记胸腺嘧啶核苷的掺入。组胺的作用是通过H2组胺受体实现的，并由淋巴细胞中cAMP浓度的增加介导。
