Roebuck B D
Lipids. 1986 Apr;21(4):281-4. doi: 10.1007/BF02536413.
Azaserine induced two phenotypically different populations of foci, namely, acidophilic and basophilic foci. The effects of dietary modification during the post-initiation phase of carcinogenesis were examined. A diet of 20% (w/w) unsaturated fat (unsat) compared to a 20% saturated fat (sat) diet or a control diet (5% unsaturated fat) increased the number of acidophilic foci, as well as the thymidine labeling index (LI) of their nuclei. While the basophilic foci are carcinogen-induced and at 2.5 mo post-initiation have a similarly high growth rate to the acidophilic foci, this rate is not sustained as indicated by examination of both the LI and mean size of foci at 4 mo post-initiation.
重氮丝氨酸诱导出两种表型不同的病灶群体，即嗜酸性病灶和嗜碱性病灶。研究了致癌作用起始后阶段饮食调整的影响。与20%饱和脂肪（饱和）饮食或对照饮食（5%不饱和脂肪）相比，20%（w/w）不饱和脂肪（不饱和）饮食增加了嗜酸性病灶的数量及其细胞核的胸腺嘧啶核苷标记指数（LI）。虽然嗜碱性病灶是致癌物诱导的，在起始后2.5个月时其生长速率与嗜酸性病灶相似，但如在起始后4个月时对LI和病灶平均大小的检查所示，该速率并未持续。
