Khoo D E, Flaks B, Oztas H, Williamson R C, Habib N A
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Int J Exp Pathol. 1991 Oct;72(5):571-80.
Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling male Leeds strain rats (n = 60) given the carcinogen azaserine. Rats were allocated to one of six groups: untreated controls (n = 10), 20% stearic acid diet (n = 10), 20% oleic acid diet (n = 10), carcinogen alone (n = 10), carcinogen plus 20% stearic acid diet (n = 10) or carcinogen plus 20% oleic acid diet (n = 10). Azaserine was administered by intraperitoneal injection in a dose of 30 mg/kg at 2, 3 and 4 weeks of age. When total lipid extracts of pancreas were examined, there was an increase in stearic acid in the stearic acid fed group and an increase in oleic acid in the oleic acid fed group, irrespective of carcinogen treatment. The relative content of all other pancreatic fatty acids was suppressed by feeding oleic acid. At 26 weeks, the number and volumetric indices of pancreatic atypical acinar cell nodules was increased only in rats given azaserine and oleic acid. The enhancing effect of oleic acid on pancreatic carcinogenesis may be associated with pancreatic fatty acid changes.
富含脂肪，尤其是不饱和脂肪的饮食会促进实验性胰腺癌的发生，但对于单个脂肪酸的影响却知之甚少。在给予致癌物偶氮丝氨酸的14日龄雄性断奶利兹品系大鼠（n = 60）中，研究了硬脂酸和油酸对胰腺脂肪酸及非典型腺泡细胞结节（癌前病变）的影响。大鼠被分为六组之一：未处理的对照组（n = 10）、20%硬脂酸饮食组（n = 10）、20%油酸饮食组（n = 10）、仅给予致癌物组（n = 10）、致癌物加20%硬脂酸饮食组（n = 10）或致癌物加（n = 10）。在2、3和4周龄时，通过腹腔注射给予偶氮丝氨酸，剂量为30 mg/kg。当检查胰腺的总脂质提取物时，无论是否进行致癌物处理，硬脂酸喂养组的硬脂酸增加，油酸喂养组的油酸增加。喂养油酸会抑制所有其他胰腺脂肪酸的相对含量。在26周时，仅在给予偶氮丝氨酸和油酸的大鼠中，胰腺非典型腺泡细胞结节的数量和体积指数增加。油酸对胰腺癌发生的促进作用可能与胰腺脂肪酸变化有关。
