Martinez-Roíg A, Camí J, Llorens-Terol J, de la Torre R, Perich F
Pediatrics. 1986 Jun;77(6):912-5.
We studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. No significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. Hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. Application of the Fisher exact probability test did not show a relationship between acetylation phenotype and hepatotoxicity.
我们研究了73例接受异烟肼和利福平治疗的患结核病儿童的乙酰化表型与肝损伤生化及临床体征出现之间的关系。在结核病患者与由256名儿童组成的对照组之间，乙酰化表型分布未发现显著差异。27例（37%）出现肝毒性，其中只有5例（7%）有临床体征。Fisher精确概率检验未显示乙酰化表型与肝毒性之间存在关联。
