Altet Gómez M N, Alcáide Megías J, Boque Genovard M A
An Esp Pediatr. 1984 Jan;20(1):18-27.
Possible toxic side-effects of antituberculous chemotherapy are studied in 718 children affected with pulmonary tuberculosis. 26 (3.62%) presented adverse side-effects and one drug had to be changed in 8 (1.11%). Treatment had to be stopped in one (0.13%) due to toxicity. Liver toxicity was specially studied, showing that younger age is a risk factor (p less than 1 X 10(-10). In 44 cases (16.54%) transient increases of no more than triple of maximum normal value, were found in SGOT and/or SGPT. Toxicity observed in controlled clinical studies and guides for treatment are exposed.
对718名患肺结核的儿童进行了抗结核化疗可能产生的毒副作用研究。26名（3.62%）出现了不良副作用，8名（1.11%）不得不更换一种药物。1名（0.13%）因毒性不得不停止治疗。专门对肝毒性进行了研究，结果表明年龄较小是一个风险因素（p小于1×10⁻¹⁰）。在44例（16.54%）中，发现谷草转氨酶（SGOT）和/或谷丙转氨酶（SGPT）短暂升高不超过正常最大值的三倍。文中阐述了在对照临床研究中观察到的毒性以及治疗指南。
