Department of Clinical Engineering, Faculty of Human Care at Makuhari, Tohto University, Chiba, Japan.
Department of Nephrology, Sangenjaya Hospital, Tokyo, Japan.
Ther Apher Dial. 2022 Oct;26(5):969-976. doi: 10.1111/1744-9987.13773. Epub 2021 Dec 14.
The clinical course of hemodialysis patients with COVID-19 still remains unclear.
Thirty-four hemodialysis patients were retrospectively enrolled. Patients were divided according to disease severity, and clinical symptoms and laboratory data at admission were compared.
The serum C-reactive protein (CRP) level, d-dimer level, and white blood cell (WBC) count were significantly higher in the group with critical disease than in the group with mild to severe disease (p = 0.005, p = 0.039, and p = 0.045). The serum CRP level exceeded 10 mg/dl within 7 days of clinical onset in all the cases with critical disease.
Hemodialysis patients with COVID-19 who have elevated serum CRP and d-dimer levels, and an elevated WBC count at admission and patients with serum CRP levels exceeding 10 mg/dl before day 7 after clinical onset should be carefully monitored for possible progression to critical disease.
COVID-19 血液透析患者的临床病程仍不清楚。
回顾性纳入 34 名血液透析患者。根据疾病严重程度进行分组，并比较入院时的临床症状和实验室数据。
重症组患者的血清 C 反应蛋白（CRP）、D-二聚体和白细胞（WBC）计数均明显高于轻症至重症组（p=0.005，p=0.039 和 p=0.045）。所有重症患者在临床发病后 7 天内血清 CRP 均超过 10mg/dl。
入院时血清 CRP、D-二聚体水平升高，WBC 计数升高，且临床发病后第 7 天前血清 CRP 水平超过 10mg/dl 的 COVID-19 血液透析患者，应密切监测其病情进展为重症的可能。
