Verugina N I, Levin O S, Lyashenko E A
Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(10. Vyp. 2):86-91. doi: 10.17116/jnevro202112110286.
Recently, an important role in the development of Parkinson's disease (PD) is assigned to the gastrointestinal tract and the enteral nervous system. In particular, the pathological process of PD begins in the gastrointestinal tract decades before progressing to the central nervous system. The microbiota-gut-brain axis is a two-way connecting system between the central nervous system and the gastrointestinal tract. The pathogenesis of PD can be caused or aggravated by changes in the gastrointestinal microbiota composition. It is shown that patients with PD have changes in the intestinal microbiota. A better understanding of gut-brain interactions and the role of the gut microbiota in regulation the immune response can both bring new knowledge about the pathological progression of PD, and contribute to the development of new diagnostic and therapeutic approaches.
最近，胃肠道和肠神经系统在帕金森病（PD）的发展中被赋予了重要作用。特别是，PD的病理过程在进展到中枢神经系统之前几十年就始于胃肠道。微生物群-肠-脑轴是中枢神经系统和胃肠道之间的双向连接系统。PD的发病机制可能由胃肠道微生物群组成的变化引起或加重。研究表明，PD患者的肠道微生物群存在变化。更好地理解肠-脑相互作用以及肠道微生物群在调节免疫反应中的作用，既可以带来关于PD病理进展的新知识，也有助于开发新的诊断和治疗方法。
