Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
ACS Nano. 2021 Dec 28;15(12):20600-20606. doi: 10.1021/acsnano.1c09325. Epub 2021 Dec 6.
Particle-based drug delivery systems have a demonstrated value in osteoarthritis treatment. Research in this area trends to developing functional particles to improve the therapeutic effects. Herein, inspired by the super lubricated surface of ice that consists of a contiguous and ultrathin layer of bound water, we developed a 2-methylacryloyloxyethyl phosphorylcholine (MPC) decorated methacrylate anhydride- hyaluronic acid (HAMA) drug delivery particle with satisfying strength and enhanced lubrication from microfluidic electrospray for osteoarthritis treatment. Benefiting from the precise control of microfluidic electrospray flows, the generated drug delivery particles are imparted with well-tailored sizes and good dispersion. As the generated HAMA particles were modified by MPC with the positively (N(CH)) and negatively (PO) charged chemical groups, they were imparted with enhanced lubrication effect and reduced friction on the joint interface by forming a hydrated lubricating layer. We have demonstrated that the MPC-modified HAMA particles could be employed as microcarriers for loading diclofenac sodium (DS) to inhibit the inflammatory response, thus further enhancing the osteoarthritis therapeutic effect and . Thus, the proposed drug delivery particles with satisfactory biocompatibility and therapeutic effect are great potential for clinical applications.
基于粒子的药物输送系统在骨关节炎治疗中具有明显的价值。该领域的研究趋势是开发功能性粒子以提高治疗效果。受由连续且超薄的结合水层组成的冰的超光滑表面的启发，我们开发了一种 2-甲基丙烯酰氧乙基磷酸胆碱（MPC）修饰的甲基丙烯酰酐-透明质酸（HAMA）药物输送粒子，通过微流控电喷雾具有令人满意的强度和增强的润滑性，用于骨关节炎治疗。受益于微流控电喷雾流的精确控制，所生成的药物输送粒子具有经过精心调整的尺寸和良好的分散性。由于生成的 HAMA 粒子被带有正电荷（N(CH))和负电荷（PO) 的 MPC 修饰，它们通过形成水合润滑层赋予了增强的润滑效果和降低关节界面的摩擦。我们已经证明，MPC 修饰的 HAMA 粒子可用作载有双氯芬酸钠（DS）的微载体以抑制炎症反应，从而进一步增强骨关节炎的治疗效果。因此，具有令人满意的生物相容性和治疗效果的所提出的药物输送粒子具有很大的临床应用潜力。
