Research Unit for Inland Development (UDI), Polytechnic Institute of Guarda, Guarda, Portugal.
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisboa, Lisboa, Portugal.
J Cosmet Dermatol. 2022 Feb;21(2):513-529. doi: 10.1111/jocd.14652. Epub 2021 Dec 6.
Currently, the demand for the use of constituents of natural origin in cosmetic formulations in detriment of synthetic compounds is noticeable. Several studies assess the potential of essential oils when incorporated into various cosmetic formulations and study their biological activities. This work intends to prepare a literature review on essential oils tested in dermocosmetic formulations and whose biological activities were evaluated through in vitro and/or in vivo tests. The main objectives for this study were as follows: to identify the essential oils that have been used in cosmetic formulations; and compile information on the main biological activities tested in cosmetic formulations.
A search was carried out until 2021 in the scientific databases PubMed and Web of Science, using different search terms, and several scientific articles from in vitro and in vivo studies in animals and clinical trials were selected and analyzed of involving development dermocosmetic formulations containing essential oils and the analysis of their biological activities.
These studies demonstrate that the antimicrobial activity (antibacterial and antifungal) is the one most studied, mainly through in vitro tests. In vivo studies were also carried out either in animals or in clinical studies showing different effects, such as repellent action, inhibition of hair growth, and action against migraine. Regarding formulations, it was evident that creams are the most used.
There is enormous potential for the use of essential oils in future formulations in the cosmetic and pharmaceutical industry, in particular as preservatives, exploring their other biological activities.
目前,人们对在化妆品配方中使用天然成分而不是合成化合物的需求明显增加。许多研究评估了将精油纳入各种化妆品配方中并研究其生物活性的潜力。本工作旨在编写一份关于在皮肤化妆品配方中测试的精油的文献综述,这些精油通过体外和/或体内试验评估了其生物活性。本研究的主要目的如下:确定已用于化妆品配方的精油;并汇编有关在化妆品配方中测试的主要生物活性的信息。
在科学数据库 PubMed 和 Web of Science 中进行了搜索,直到 2021 年,使用了不同的搜索词,并选择和分析了涉及开发含有精油的皮肤化妆品配方及其生物活性分析的动物体内和临床试验的许多科学文章。
这些研究表明,抗菌活性(抗细菌和抗真菌)是研究最多的,主要通过体外试验进行研究。还在动物或临床试验中进行了体内研究,显示出不同的效果,例如驱避作用、抑制头发生长和偏头痛作用。关于配方,显然乳膏是最常用的。
在未来的化妆品和制药行业的配方中,精油具有巨大的应用潜力,特别是作为防腐剂,可以探索其其他生物活性。