Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Schizophr Res. 2022 Jan;239:111-115. doi: 10.1016/j.schres.2021.11.015. Epub 2021 Dec 4.
Autistic traits are associated with psychotic experiences in adolescence; however, the mechanisms underlying this relationship are not well understood. Prior research indicates that bullying victimization increases the risk of psychotic experiences in general adolescent populations, and autistic youth are at higher risk of being bullied than their non-autistic peers. Using longitudinal data from general population adolescents aged 10-14 in the Tokyo Teen Cohort study, we tested the hypothesis that bullying is responsible for the association between autistic traits and psychotic experiences in adolescence. We identified an indirect effect (estimate = 0.033 [95% CIs: 0.014-0.057], p < 0.001) between autistic traits and psychotic experiences via bullying victimization, even after controlling for known confounders. Prevention of bullying victimization may be one avenue for reducing risk of psychosis among adolescents with high levels of autistic traits.
自闭症特质与青少年时期的精神病性体验有关；然而，这种关系的潜在机制尚不清楚。先前的研究表明，在一般青少年群体中，受欺凌会增加出现精神病性体验的风险，而自闭症青少年比非自闭症同龄人更容易成为欺凌的对象。本研究使用来自东京青少年队列研究中 10-14 岁普通人群青少年的纵向数据，检验了欺凌行为是导致自闭症特质与青少年时期精神病性体验之间关联的假设。研究发现，即使在控制了已知的混杂因素后，自闭症特质与精神病性体验之间仍存在通过欺凌受害行为产生的间接效应（估计值=0.033[95%置信区间：0.014-0.057]，p<0.001）。预防欺凌受害行为可能是降低自闭症特质较高的青少年出现精神病风险的一种途径。
