超重与规律月经周期不孕女性持续性无排卵的相关性：病例对照研究。
Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study.
机构信息
Unidade Acadêmica de Ciências da Saúde, Universidade Federal de Jataí, Jataí, GO, Brazil.
Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Hospital das Clínicas, Laboratório de Reprodução Humana, Universidade Federal de Goiás, Goiânia, GO, Brazil.
出版信息
Rev Bras Ginecol Obstet. 2021 Nov;43(11):834-839. doi: 10.1055/s-0041-1739464. Epub 2021 Dec 6.
OBJECTIVE
It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles.
METHODS
We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m) and overweight (BMI: 25.0-29.9kg/m).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels.
RESULTS
Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels > 5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98).
CONCLUSION
Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.
目的
超重可能是不孕结局的一个危险因素。本研究旨在评估月经周期规律的不孕妇女超重与排卵障碍之间的关系。
方法
我们进行了一项回顾性病例对照研究，纳入了接受辅助生殖治疗的持续排卵障碍患者。患者分为正常体重组（BMI：18.5-24.9kg/m）和超重组（BMI：25.0-29.9kg/m）。排除多囊卵巢综合征或肥胖患者。两组在年龄、不孕持续时间、催乳素、卵泡刺激素（FSH）、促甲状腺激素（TSH）、黄体生成素（LH）和雌二醇水平方面进行了匹配。
结果
当使用世界卫生组织（WHO）排卵障碍标准时，超重与排卵障碍显著相关：孕酮水平>5.65ng/ml 且超声检查显示卵泡塌陷（比值比[OR]：2.69；95%置信区间[CI95%]：1.04-6.98）。
结论
对于月经周期规律的非肥胖不孕妇女，BMI 超过正常范围会影响排卵。
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