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超重与规律月经周期不孕女性持续性无排卵的相关性：病例对照研究。

Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study.

机构信息

Unidade Acadêmica de Ciências da Saúde, Universidade Federal de Jataí, Jataí, GO, Brazil.

Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Hospital das Clínicas, Laboratório de Reprodução Humana, Universidade Federal de Goiás, Goiânia, GO, Brazil.

出版信息

Rev Bras Ginecol Obstet. 2021 Nov;43(11):834-839. doi: 10.1055/s-0041-1739464. Epub 2021 Dec 6.

DOI:10.1055/s-0041-1739464
PMID:34872141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10183939/
Abstract

OBJECTIVE

It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles.

METHODS

We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m) and overweight (BMI: 25.0-29.9kg/m).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels.

RESULTS

Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels > 5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98).

CONCLUSION

Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.

摘要

目的

超重可能是不孕结局的一个危险因素。本研究旨在评估月经周期规律的不孕妇女超重与排卵障碍之间的关系。

方法

我们进行了一项回顾性病例对照研究，纳入了接受辅助生殖治疗的持续排卵障碍患者。患者分为正常体重组（BMI：18.5-24.9kg/m）和超重组（BMI：25.0-29.9kg/m）。排除多囊卵巢综合征或肥胖患者。两组在年龄、不孕持续时间、催乳素、卵泡刺激素（FSH）、促甲状腺激素（TSH）、黄体生成素（LH）和雌二醇水平方面进行了匹配。

结果

当使用世界卫生组织（WHO）排卵障碍标准时，超重与排卵障碍显著相关：孕酮水平>5.65ng/ml 且超声检查显示卵泡塌陷（比值比[OR]：2.69；95%置信区间[CI95%]：1.04-6.98）。

结论

对于月经周期规律的非肥胖不孕妇女，BMI 超过正常范围会影响排卵。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf2/10183939/e119f369b578/10-1055-s-0041-1739464-i190325-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf2/10183939/c403b95059e1/10-1055-s-0041-1739464-i190325-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf2/10183939/e119f369b578/10-1055-s-0041-1739464-i190325-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf2/10183939/c403b95059e1/10-1055-s-0041-1739464-i190325-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf2/10183939/e119f369b578/10-1055-s-0041-1739464-i190325-2.jpg

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本文引用的文献

1
The experiences of women with polycystic ovary syndrome on a very low-calorie diet.患有多囊卵巢综合征的女性在极低热量饮食方面的经历。
Int J Womens Health. 2016 Jul 21;8:299-310. doi: 10.2147/IJWH.S100385. eCollection 2016.
2
Diagnostic evaluation of the infertile female: a committee opinion.女性不孕的诊断评估：委员会意见。
Fertil Steril. 2015 Jun;103(6):e44-50. doi: 10.1016/j.fertnstert.2015.03.019. Epub 2015 Apr 30.
3
Female infertility of endocrine origin.内分泌源性女性不孕症。
FIGO 排卵障碍分类系统。
Int J Gynaecol Obstet. 2022 Oct;159(1):1-20. doi: 10.1002/ijgo.14331. Epub 2022 Aug 19.
Arq Bras Endocrinol Metabol. 2014 Mar;58(2):144-52. doi: 10.1590/0004-2730000003021.
4
Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.体重指数和短期体重变化与接受辅助生殖治疗的女性的治疗结局的关系。
Fertil Steril. 2012 Jul;98(1):109-16. doi: 10.1016/j.fertnstert.2012.04.012. Epub 2012 May 16.
5
Characteristics of infertile patients with ovulatory dysfunction and their relation to body mass index.排卵功能障碍不孕患者的特征及其与体重指数的关系。
J Ayub Med Coll Abbottabad. 2009 Jul-Sep;21(3):12-6.
6
The subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility.皮下腹部脂肪与肥胖和不孕女性的排卵障碍有关，而不是与腹腔内脂肪有关。
J Clin Endocrinol Metab. 2010 May;95(5):2107-12. doi: 10.1210/jc.2009-1915. Epub 2010 Mar 3.
7
Overweight and obesity in infertility: cost and consequences.不孕症中的超重与肥胖：成本及后果
Hum Reprod Update. 2010 May-Jun;16(3):229-30. doi: 10.1093/humupd/dmp058. Epub 2010 Jan 7.
8
Obesity and its relationship to infertility in men and women.肥胖及其与男性和女性不孕的关系。
Obstet Gynecol Clin North Am. 2009 Jun;36(2):333-46, ix. doi: 10.1016/j.ogc.2009.03.002.
9
The impact of body mass index on assisted reproduction.体重指数对辅助生殖的影响。
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10
Impact of obesity on female fertility and fertility treatment.肥胖对女性生育能力及辅助生殖治疗的影响。
Womens Health (Lond). 2008 Mar;4(2):183-94. doi: 10.2217/17455057.4.2.183.