Sadia Shamsunnisa, Waqar Fareesa, Akhtar Tasneem, Sultana Sadia
Department of Obstetrics and Gynaecology, Islamic International Medical College, Rawalpindi, Pakistan.
J Ayub Med Coll Abbottabad. 2009 Jul-Sep;21(3):12-6.
Ovulatory dysfunction is a group of disorders with variable clinical presentations occasionally having serious long-term adverse effects. It accounts for 30% of female fertility problems. Evidence suggests an association between an individual's weight and disorders of ovulation. The objective of our study was to describe the clinical and hormonal profile of subfertile women with ovulatory dysfunction in relation to their body mass index (BMI).
This prospective, descriptive study was carried out in Mother and Child Health Centre, PIMS, Islamabad and Railway hospital, Rawalpindi from April 2001 to March 2007. One hundred & thirty eight infertile patients with ovulatory dysfunction were included. The clinical data including BMI of each patient was recorded in addition to reports of investigations comprised of cervical smear, pelvic ultrasound and hormonal profile.
Primary infertility was found in 61% while secondary in 39% of the patients. The mean age was 29 years and mean duration of infertility was 6 years. Menstrual pattern was normal in 56.5%. BMI was normal in 30.4% while most patients were overweight and obese. Prolonged cycles, history of systemic endocrine disorders, abnormal vaginal discharge, hirsutism, polycystic ovarian morphology and hormonal abnormalities were more frequent in patients with increased BMI. During the study period, 21.7% of the women conceived.
Infertile patients with ovulatory dysfunction present more frequently with primary infertility. They usually have higher than required BMI. Oligomenorrhoea amenorrhoea, hirsutism and hormonal abnormalities are more frequent in overweight than infertile patients with ovulatory dysfunction having a normal BMI.
排卵功能障碍是一组临床表现多样的疾病，偶尔会产生严重的长期不良影响。它占女性生育问题的30%。有证据表明个体体重与排卵障碍之间存在关联。我们研究的目的是描述排卵功能障碍的亚生育期女性的临床和激素特征与其体重指数（BMI）的关系。
这项前瞻性描述性研究于2001年4月至2007年3月在伊斯兰堡的PIMS母婴健康中心和拉瓦尔品第的铁路医院进行。纳入了138例排卵功能障碍的不孕患者。除了宫颈涂片、盆腔超声和激素水平检查报告外，还记录了包括每位患者BMI在内的临床数据。
61%的患者为原发性不孕，39%为继发性不孕。平均年龄为29岁，平均不孕时间为6年。56.5%的患者月经模式正常。30.4%的患者BMI正常，而大多数患者超重或肥胖。BMI升高的患者中，月经周期延长、系统性内分泌疾病史、异常白带、多毛症、多囊卵巢形态和激素异常更为常见。在研究期间，21.7%的女性怀孕。
排卵功能障碍的不孕患者原发性不孕更为常见。他们的BMI通常高于正常水平。与BMI正常的排卵功能障碍不孕患者相比，超重患者中月经过少、闭经、多毛症和激素异常更为常见。
