University of Wisconsin, Madison, WI, USA.
Vet Pathol. 2022 Mar;59(2):358-370. doi: 10.1177/03009858211052664. Epub 2021 Dec 6.
In a retrospective study of a western pygmy marmoset () colony, postmortem examination of 1/8 juvenile and 29/47 adult animals identified vascular, cardiac, and renal lesions consistent with systemic hypertension. This included frequent renal arteriolar hypertrophy, hyaline and proliferative arteriolosclerosis, fibrinoid necrosis of arterioles, glomerulosclerosis, and nephrosclerosis. Affected animals ranged from 0.6 to 12 years of age (mean 6 years) and had an observed male predominance. Genealogical relatedness was evident in several breeding pairs and spanned multiple generations. Concurrent cardiac and renal disease was commonly identified, although frequently subclinical, and both were important causes of morbidity and mortality in affected animals. Cardiomegaly and hypertrophy were typical features and were accompanied by left atrial thrombosis in 10 animals. Signs of heart failure included chronic pulmonary edema in 20 cases and body cavity effusions in 17. In the kidneys, 19 cases had glomerular disease and hypertensive vasculopathy, and 26 cases had nephrosclerosis or glomerulosclerosis. Common extrarenal secondary causes of hypertension were excluded by necropsy examination. The pathogenesis is suggested to involve primary hypertension leading to renal and cardiac disease. Elevated sympathetic activity might be an underlying factor in the frequent development of primary systemic hypertension in the pygmy marmoset, as for the owl monkey.
在对西部侏狨猴（）群体的回顾性研究中，对 1/8 只幼年动物和 29/47 只成年动物进行的尸检发现了与系统性高血压一致的血管、心脏和肾脏病变。这包括频繁的肾小动脉肥大、玻璃样和增生性小动脉硬化、小动脉纤维素样坏死、肾小球硬化和肾硬化。受影响的动物年龄从 0.6 岁到 12 岁不等（平均 6 岁），且雄性占优势。在几个繁殖对中可以明显看出家族相关性，并跨越了多个世代。同时存在心脏和肾脏疾病很常见，尽管通常是亚临床的，但这两种疾病都是受影响动物发病率和死亡率的重要原因。心脏肥大和心肌肥厚是典型特征，10 只动物伴有左心房血栓形成。心力衰竭的迹象包括 20 例慢性肺水肿和 17 例体腔积液。在肾脏中，19 例有肾小球疾病和高血压性血管病变，26 例有肾硬化或肾小球硬化。尸检排除了常见的继发性高血压的继发原因。发病机制提示原发性高血压导致肾脏和心脏疾病。交感神经活动的增加可能是西部侏狨猴（与猫头鹰猴一样）原发性系统性高血压频繁发生的潜在因素。
