Slauson D O, Hobbs C H, Crain C
Vet Pathol. 1978 Jan;15(1):1-11. doi: 10.1177/030098587801500101.
Syrian hamsters developed spontaneous renal lesions that resembled those of arteriolar nephrosclerosis in man, and differed from other spontaneously occurring or virus-induced renal diseases in other rodent species. Morphologic changes were mainly degenerative with little cellular exudation and were associated with histologic changes in the intrarenal vasculature. The renal lesions were progressive, often fatal and sometimes were complicated by glomerular amyloidosis with the nephrotic syndrome and uremia. Endstage kidneys often had fibrinoid necrosis of intrarenal arterioles and thus resembled lesions characteristic of the malignant phase of human essential hypertension. Fibrinoid necrosis of small arterioles was common in the uterus, ovaries or testes of affected animals; it was less frequent in mesenteric or coronary vessels. Cardiac thrombosis, often involving the left atrium or left atrioventricular valves, also was common. Changes occurred earlier and often were more severe in females than in males. This disease was a major cause of morbidity and mortality and hampered life-span studies.
叙利亚仓鼠会出现自发性肾脏病变，这些病变类似于人类的小动脉性肾硬化，且与其他啮齿动物物种中其他自发出现或病毒诱导的肾脏疾病不同。形态学变化主要是退行性的，几乎没有细胞渗出，并且与肾内血管系统的组织学变化有关。肾脏病变呈进行性发展，常常致命，有时还会并发伴有肾病综合征和尿毒症的肾小球淀粉样变性。终末期肾脏常出现肾内小动脉的纤维素样坏死，因此类似于人类原发性高血压恶性阶段的特征性病变。小动脉的纤维素样坏死在患病动物的子宫、卵巢或睾丸中很常见；在肠系膜或冠状血管中则较少见。心脏血栓形成也很常见，常累及左心房或左房室瓣。这些变化在雌性中比在雄性中出现得更早，且往往更严重。这种疾病是发病和死亡的主要原因，阻碍了寿命研究。
