转移的进化：新工具和新见解。
Evolution of metastasis: new tools and insights.
机构信息
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Trends Cancer. 2022 Feb;8(2):98-109. doi: 10.1016/j.trecan.2021.11.002. Epub 2021 Dec 3.
Metastasis is an evolutionary process occurring across multiple organs and timescales. Due to its continuous and dynamic nature, this multifaceted process has been challenging to investigate and remains incompletely understood, in part due to the lack of tools capable of probing genomic evolution at high enough resolution. However, technological advances in genetic sequencing and editing have provided new and powerful methods to refine our understanding of the complex series of events that lead to metastatic dissemination. In this review, we summarize the latest genetic and lineage-tracing approaches developed to unravel the genetic evolution of metastasis. The findings that have emerged have enhanced our comprehension of the mechanistic trajectories and timescales of metastasis and could provide new strategies for therapy.
转移是一个在多个器官和时间尺度上发生的进化过程。由于其连续性和动态性，这个多方面的过程一直难以研究，部分原因是缺乏能够以足够高的分辨率探测基因组进化的工具。然而，遗传测序和编辑技术的进步为深化我们对导致转移扩散的复杂事件序列的理解提供了新的强大方法。在这篇综述中，我们总结了为揭示转移的遗传进化而开发的最新遗传和谱系追踪方法。所获得的发现增强了我们对转移的机制轨迹和时间尺度的理解，并为治疗提供了新的策略。
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