Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Internal Medicine, Velayat Clinical Research Development Unit, Qazvin University of Medical Sciences, Qazvin, Iran.
Turk J Gastroenterol. 2021 Nov;32(11):937-944. doi: 10.5152/tjg.2021.20344.
The quality of sleep in people with irritable bowel syndrome (IBS) is reduced by increased oxidative stress and clinical problems. Assessing the effects of ellagic acid (EA) on sleep quality and gastrointestinal symptoms in patients with IBS was the aim of this study.
In this research that was conducted as a randomized, double-blind, placebo-controlled clinical trial, 44 patients with IBS were enlisted. Individuals approved by the project clinical counselor were divided into two intervention groups to receive 180 mg of EA per day (n = 22) and a placebo group (n = 22) for 2 months. Petersburg's Sleep Quality (PSQI) questionnaire and IBS severity score system (IBSSS) were assessed at the beginning and end of the study. Statistical analysis was performed using SPSS software.
At the end of the study, changes in mean PSQI and scores related to sleep subgroups were significant between the two groups (P < .05). Also, the significant changes were not seen in sleep and sleep subgroups scores in the placebo group at the end of the study (P > .05). EA consumption reduced IBSSS score and IBS symptoms in the intervention group after 2 months (P < .05).
The results arisen from this study indicated that receiving EA had a beneficial effect on sleep quality and gastrointestinal symptoms in IBS patients. The antioxidant and anti-inflammatory properties of EA may be responsible for these beneficial effects.
肠易激综合征（IBS）患者的睡眠质量因氧化应激增加和临床问题而降低。本研究旨在评估鞣花酸（EA）对 IBS 患者睡眠质量和胃肠道症状的影响。
在这项随机、双盲、安慰剂对照的临床试验中，纳入了 44 名 IBS 患者。项目临床顾问批准的个体被分为两组，分别接受每天 180 毫克 EA（n = 22）和安慰剂组（n = 22），为期 2 个月。在研究开始和结束时，使用匹兹堡睡眠质量指数（PSQI）问卷和 IBS 严重程度评分系统（IBSSS）评估。使用 SPSS 软件进行统计分析。
研究结束时，两组之间 PSQI 平均值和与睡眠亚组相关的评分变化均具有统计学意义（P <.05）。此外，安慰剂组在研究结束时睡眠和睡眠亚组评分没有显著变化（P >.05）。干预组在 2 个月后 EA 摄入降低了 IBSSS 评分和 IBS 症状（P <.05）。
本研究结果表明，EA 摄入对 IBS 患者的睡眠质量和胃肠道症状有有益影响。EA 的抗氧化和抗炎特性可能是这些有益影响的原因。
