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澳大利亚护士上门探访项目的经济评价:3 年随机试验。

Economic evaluation of an Australian nurse home visiting programme: a randomised trial at 3 years.

机构信息

School of Health and Social Development, Deakin University, Burwood, VIC, 3125, Australia

Population Health, Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia.

出版信息

BMJ Open. 2021 Dec 6;11(12):e052156. doi: 10.1136/bmjopen-2021-052156.

Abstract

OBJECTIVES

To investigate the additional programme cost and cost-effectiveness of 'right@home' Nurse Home Visiting (NHV) programme in relation to improving maternal and child outcomes at child age 3 years compared with usual care.

DESIGN

A cost-utility analysis from a government-as-payer perspective alongside a randomised trial of NHV over 3-year period. Costs and quality-adjusted life-years (QALYs) were discounted at 5%. Analysis used an intention-to-treat approach with multiple imputation.

SETTING

The right@home was implemented from 2013 in Victoria and Tasmania states of Australia, as a primary care service for pregnant women, delivered until child age 2 years.

PARTICIPANTS

722 pregnant Australian women experiencing adversity received NHV (n=363) or usual care (clinic visits) (n=359).

PRIMARY AND SECONDARY OUTCOME MEASURES

First, a cost-consequences analysis to compare the additional costs of NHV over usual care, accounting for any reduced costs of service use, and impacts on all maternal and child outcomes assessed at 3 years. Second, cost-utility analysis from a government-as-payer perspective compared additional costs to maternal QALYs to express cost-effectiveness in terms of additional cost per additional QALY gained.

RESULTS

When compared with usual care at child age 3 years, the right@home intervention cost $A7685 extra per woman (95% CI $A7006 to $A8364) and generated 0.01 more QALYs (95% CI -0.01 to 0.02). The probability of right@home being cost-effective by child age 3 years is less than 20%, at a willingness-to-pay threshold of $A50 000 per QALY.

CONCLUSIONS

Benefits of NHV to parenting at 2 years and maternal health and well-being at 3 years translate into marginal maternal QALY gains. Like previous cost-effectiveness results for NHV programmes, right@home is not cost-effective at 3 years. Given the relatively high up-front costs of NHV, long-term follow-up is needed to assess the accrual of health and economic benefits over time.

TRIAL REGISTRATION NUMBER

ISRCTN89962120.

摘要

目的

调查“在家即安”(right@home)护士家访(NHV)项目相较于常规护理在改善母婴结局方面的额外项目成本和成本效益,随访至儿童 3 岁。

设计

从政府支付者的角度进行成本-效用分析,并对 3 年期间的 NHV 进行随机试验。成本和质量调整生命年(QALYs)贴现率为 5%。分析采用意向治疗方法和多重插补。

地点

right@home 于 2013 年在澳大利亚维多利亚州和塔斯马尼亚州实施,作为孕妇的初级保健服务,持续至儿童 2 岁。

参与者

722 名澳大利亚处境不利的孕妇接受 NHV(n=363)或常规护理(就诊)(n=359)。

主要和次要结局测量

首先,进行成本-后果分析,比较 NHV 相较于常规护理的额外成本,同时考虑任何服务使用成本的降低,并评估 3 年时的所有母婴结局。其次,从政府支付者的角度进行成本-效用分析,将额外成本与产妇 QALYs 进行比较,以获得每额外 QALY 增加的额外成本来表达成本效益。

结果

与儿童 3 岁时的常规护理相比,right@home 干预的每位女性额外花费 7685 澳元(95%CI 7006 澳元至 8364 澳元),并增加 0.01 个 QALY(95%CI -0.01 至 0.02)。right@home 在儿童 3 岁时具有成本效益的概率小于 20%,在支付意愿阈值为 50000 澳元/QALY 时。

结论

NHV 在 2 岁时对育儿的益处以及在 3 岁时对产妇健康和幸福感的益处转化为边际产妇 QALY 获益。与 NHV 项目之前的成本效益结果一样,right@home 在 3 岁时并不具有成本效益。鉴于 NHV 的前期成本相对较高,需要进行长期随访以评估随着时间的推移健康和经济效益的累计。

试验注册号

ISRCTN89962120。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8b/8650480/6ad8a9a5c696/bmjopen-2021-052156f01.jpg

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