Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany
Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
BMJ Open. 2021 Dec 6;11(12):e053497. doi: 10.1136/bmjopen-2021-053497.
Alcohol use is a major risk factor for mortality. Previous studies suggest that the alcohol-attributable mortality burden is higher in lower socioeconomic strata. This project will test the hypothesis that the 2017 increase of alcohol excise taxes linked to lower all-cause mortality rates in previous analyses will reduce socioeconomic mortality inequalities.
Data on all causes of deaths will be obtained from Statistics Lithuania. Record linkage will be implemented using personal identifiers combining data from (1) the 2011 whole-population census, (2) death records between 1 March 2011 (census date) and 31 December 2019, and (3) emigration records, for individuals aged 40-70 years. The analyses will be performed separately for all-cause and for alcohol-attributable deaths. Monthly age-standardised mortality rates will be calculated by sex, education and three measures of socioeconomic status (SES). Inequalities in mortality will be assessed using absolute and relative indicators between low and high SES groups. We will perform interrupted time series analyses, and test the impact of the 2017 rise in alcohol excise taxation using generalised additive mixed models. In these models, we will control for secular trends for economic development.
This work is part of project grant 1R01AA028224-01 by the National Institute on Alcohol Abuse and Alcoholism. It has been granted research ethics approval 050/2020 by Centre for Addiction and Mental Health Research Ethics Board on 17 April 2020, renewed on 30 March 2021. The time series of mortality inequalities as well as the statistical code will be made publicly available, allowing other researchers to adapt the proposed method to other jurisdictions.
饮酒是导致死亡的一个主要风险因素。先前的研究表明，较低社会经济阶层的酒精相关死亡率负担更高。本项目将检验以下假设，即在先前分析中，与较低全因死亡率相关的 2017 年酒类消费税增加将减少社会经济死亡率不平等。
所有死因数据将从立陶宛统计局获得。记录链接将通过个人标识符来实现，该标识符结合了（1）2011 年全国人口普查、（2）2011 年 3 月 1 日（普查日）至 2019 年 12 月 31 日期间的死亡记录和（3）移民记录的数据，针对年龄在 40-70 岁的个体。分析将分别针对全因和酒精相关死亡进行。按性别、教育程度和三种社会经济地位（SES）指标计算每月年龄标准化死亡率。死亡率不平等将通过低 SES 和高 SES 组之间的绝对和相对指标进行评估。我们将进行中断时间序列分析，并使用广义加性混合模型测试 2017 年酒类消费税上涨的影响。在这些模型中，我们将控制经济发展的长期趋势。
这项工作是美国国家酒精滥用与酒精中毒研究所授予的项目资助 1R01AA028224-01 的一部分。它已于 2020 年 4 月 17 日由成瘾与心理健康研究伦理委员会授予研究伦理批准[050/2020]，并于 2021 年 3 月 30 日更新。死亡率不平等的时间序列以及统计代码将公开提供，允许其他研究人员将所提出的方法应用于其他司法管辖区。
