亚急性硬化性全脑炎的磁共振成像：两例报告及文献综述

Magnetic Resonance Imaging in Subacute Sclerosing Panencephalitis: Two Case Reports and Review of Literature.

作者信息

Barthwal Saumitra, Kaur Narinder, Kaur Ravinder, Zaidi Ruma, Randev Shivani

机构信息

Radiodiagnosis, Government Medical College and Hospital, Chandigarh, IND.

Pediatrics, Government Medical College and Hospital, Chandigarh, IND.

出版信息

Cureus. 2021 Oct 31;13(10):e19161. doi: 10.7759/cureus.19161. eCollection 2021 Oct.

DOI:10.7759/cureus.19161

PMID:34873504

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8631486/

Abstract

Subacute sclerosing panencephalitis (SSPE) is a slowly progressive neurodegenerative disease caused by the measles virus. This study investigated the magnetic resonance imaging (MRI) findings in SSPE by retrospective review of two cases diagnosed by typical periodic electroencephalographic (EEG) features, clinical symptoms and elevated measles antibody titre in cerebrospinal fluid (CSF). MRI revealed lesions of high signal intensity on T2-weighted images involving the periventricular or subcortical white matter in both the patients. Both these patients were given sodium valproate for seizures. However, the disease proved fatal in both these cases eventually.

摘要

亚急性硬化性全脑炎（SSPE）是一种由麻疹病毒引起的缓慢进展性神经退行性疾病。本研究通过回顾性分析两例经典型周期性脑电图（EEG）特征、临床症状及脑脊液（CSF）中麻疹抗体滴度升高确诊的病例，探讨了SSPE的磁共振成像（MRI）表现。MRI显示，两名患者的T2加权图像上均有高信号强度病变，累及脑室周围或皮质下白质。这两名患者均因癫痫发作接受了丙戊酸钠治疗。然而，这两例患者最终均死亡。