Department of Medicine, Medical College of Wisconsin, Medical School, Milwaukee, Wisconsin, USA.
Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Alzheimers Dement. 2022 Sep;18(9):1616-1624. doi: 10.1002/alz.12521. Epub 2021 Dec 7.
To understand the relationship between mortality and cognitive function among older US Hispanic adults with and without diabetes.
Data from the Health and Retirement Study (1995-2014) were analyzed. Cox proportional hazard models were used to estimate the association between mortality and cognitive function. Models were stratified by diabetes.
Four thousand thirteen older US Hispanic adults were included. Fully adjusted models for individuals with diabetes showed those with mild cognitive impairment (MCI; hazard ratio [HR]: 1.61; 95% confidence interval [CI]: 1.06, 2.45; P = .025) and dementia (HR: 2.14; 95% CI: 1.25, 3.67; P = .006) had increased mortality compared to normal cognition. Fully adjusted models for individuals without diabetes showed those with MCI (HR: 1.87; 95% CI: 1.28, 2.74; P = .001) and dementia (HR: 3.25; 95% CI: 1.91, 5.55; P < .001) had increased mortality compared to normal cognition.
Cognitive impairment is associated with increased mortality in older US Hispanic adults with and without diabetes. Clinicians should regularly assess cognitive function in this group to quickly identify declines and make appropriate referrals for support to optimize health and reduce mortality.
了解美国西班牙裔老年成年人中有无糖尿病患者的死亡率与认知功能之间的关系。
对健康与退休研究（1995-2014 年）的数据进行了分析。采用 Cox 比例风险模型来评估死亡率与认知功能之间的关系。模型按糖尿病进行分层。
共纳入 4013 名美国西班牙裔老年人。对于有糖尿病的个体，经过充分调整的模型显示，轻度认知障碍（MCI；风险比 [HR]：1.61；95%置信区间 [CI]：1.06，2.45；P=0.025）和痴呆（HR：2.14；95%CI：1.25，3.67；P=0.006）患者的死亡率较认知正常者有所升高。对于无糖尿病的个体，经过充分调整的模型显示，MCI（HR：1.87；95%CI：1.28，2.74；P=0.001）和痴呆（HR：3.25；95%CI：1.91，5.55；P<0.001）患者的死亡率较认知正常者有所升高。
认知障碍与美国西班牙裔老年成年人中有无糖尿病患者的死亡率增加有关。临床医生应定期评估该人群的认知功能，以便快速识别认知下降并进行适当的转介，以获得支持，从而优化健康状况并降低死亡率。
