Department of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, San Diego, CA, USA.
Department of Healthcare Sciences, Wayne State University, Institute of Gerontology, Detroit, MI, USA.
Alzheimers Dement. 2019 Dec;15(12):1507-1515. doi: 10.1016/j.jalz.2019.08.202. Epub 2019 Nov 18.
We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.
Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging-Alzheimer's Association diagnostic criteria.
The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.
MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
我们评估了中年和老年不同族裔的西班牙裔/拉丁裔人群中轻度认知障碍（MCI）的患病率及其相关因素。
这项多中心前瞻性队列研究招募了（n=6377；50-86 岁）中年和老年不同族裔的西班牙裔/拉丁裔，使用国家老龄化研究所-阿尔茨海默病协会的诊断标准评估 MCI。
总的 MCI 患病率为 9.8%，不同西班牙裔/拉丁裔群体之间存在差异。年龄较大、心血管疾病（CVD）风险高和抑郁症状加重是 MCI 患病率的显著相关因素。载脂蛋白 E4（APOE4）和 APOE2 与 MCI 无显著相关性。
MCI 的患病率在西班牙裔/拉丁裔背景之间存在差异，但不如以前的研究报告的那样广泛。CVD 风险和抑郁症状与 MCI 增加有关，而 APOE4 则没有，这表明不同族裔的西班牙裔/拉丁裔人群中 MCI 的病因可能不同。我们的研究结果表明，减轻 CVD 风险因素可能为理解和减少不同族裔的西班牙裔/拉丁裔人群中的 MCI 乃至痴呆症提供重要途径。
