Dahl R, Venge P
Scand J Respir Dis. 1978;59(6):319-22.
The in vivo effect of beta-2-adrenergic stimulating and blocking drugs and of corticosteroid medication on blood eosinophils and serum eosinophil cationic protein (S-ECP) has been studied. The beta-2-adrenergic drugs, salbutamol and terbutaline, had an eosinopenic effect. They were able to decrease S-ECP concentration, which administration of steroid was not, indicating that only the adrenergic stimulators affect leucocyte secretion. Care must be taken in interpretation of blood eosinophil count and S-ECP concentration, and the actual medical treatment must be known.
已经研究了β-2-肾上腺素能激动剂和阻滞剂以及皮质类固醇药物对血液嗜酸性粒细胞和血清嗜酸性粒细胞阳离子蛋白(S-ECP)的体内作用。β-2-肾上腺素能药物沙丁胺醇和特布他林具有嗜酸性粒细胞减少作用。它们能够降低S-ECP浓度,而类固醇药物则不能,这表明只有肾上腺素能刺激剂会影响白细胞分泌。在解释血液嗜酸性粒细胞计数和S-ECP浓度时必须谨慎,并且必须了解实际的药物治疗情况。