一种低等脊椎动物中降钙素基因的分离与部分特性分析。禽降钙素基因相关肽的预测结构。
Isolation and partial characterization of the calcitonin gene in a lower vertebrate. Predicted structure of avian calcitonin gene-related peptide.
作者信息
Minvielle S, Cressent M, Lasmoles F, Jullienne A, Milhaud G, Moukhtar M S
出版信息
FEBS Lett. 1986 Jul 14;203(1):7-10. doi: 10.1016/0014-5793(86)81425-9.
PMID:3487468
Abstract
The gene coding for calcitonin was isolated and characterized in a non-mammalian vertebrate, chicken. Sequencing of the 3'-end of this gene revealed after the calcitonin coding exon, an intron followed by an exon coding for a calcitonin gene-related peptide, which displays significant amino acid sequence homology with mammalian CGRPs so far sequenced.
摘要
编码降钙素的基因在一种非哺乳类脊椎动物——鸡中被分离并进行了特征分析。对该基因3'端进行测序后发现，在降钙素编码外显子之后，有一个内含子，接着是一个编码降钙素基因相关肽的外显子，该肽与迄今已测序的哺乳动物降钙素基因相关肽显示出显著的氨基酸序列同源性。
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