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抗真菌药物耐药性：解析真菌病原体光滑念珠菌中多药耐药性的机制。

Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata.

机构信息

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada.

出版信息

Curr Biol. 2021 Dec 6;31(23):R1520-R1523. doi: 10.1016/j.cub.2021.09.071.

DOI:10.1016/j.cub.2021.09.071
PMID:34875240
Abstract

Fungal infections pose a significant health burden. In a new study, Candida glabrata isolates resistant to mechanistically distinct antifungals were evolved, unveiling mutations in ERG3 as a novel mechanism by which this pathogen evolves multidrug resistance.

摘要

真菌感染带来了重大的健康负担。在一项新的研究中，耐药机制不同的抗真菌药物的光滑念珠菌分离株进化了，揭示了 ERG3 突变是该病原体产生多药耐药性的新机制。

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