草药漱口水对牙龈炎患者牙菌斑和炎症控制的影响：一项随机对照试验的系统评价和荟萃分析
Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
作者信息
Cai He, Chen Junyu, Panagodage Perera Nirmala K, Liang Xing
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, South Renmin Road, Chengdu 610041, China.
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, South Renmin Road, Chengdu 610041, China.
出版信息
Evid Based Complement Alternat Med. 2020 Jan 20;2020:2829854. doi: 10.1155/2020/2829854. eCollection 2020.
OBJECTIVE
The aim of this study was to evaluate the overall effects of herbal mouthwashes as supplements to daily oral hygiene on plaque and inflammation control compared with placebos and chlorhexidine (CHX) mouthwashes in the treatment of gingivitis.
METHODS
PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and grey literature databases were searched. Only randomised controlled trials (RCTs) comparing herbal mouthwashes with placebos or CHX in the daily oral hygiene of patient with gingivitis were included to compare the effect of different mouthwashes on plaque and inflammation control.
RESULTS
A total of 13 studies satisfied the eligibility criteria, and 11 studies were included in meta-analyses. Significant differences were observed in favour of herbal mouthwashes compared with placebos in both plaque- and inflammation-related indices (Quigley-Hein Plaque Index, QHPI: WMD = -0.61, 95% CI (-0.80, -0.42), < 0.001; Gingival Index, GI: -0.28 (-0.51, -0.06), =0.01; Modified Gingival Index, MGI: -0.59 (-1.08, -0.11), =0.02; Gingival Bleeding Index, GBI: -0.06 (-0.09, -0.04), < 0.001). No significant difference was found between herbal and CHX mouthwashes.
CONCLUSIONS
Herbal mouthwashes have potential benefits in plaque and inflammation control as supplements to the daily oral hygiene of patients with gingivitis. Although no difference was observed between herbal and CHX mouthwashes in the selected studies, further high-quality RCTs are needed for more firm support before advising patients with gingivitis about whether they can use herbal mouthwashes to substitute for CHX mouthwashes or not (: CRD42019122841).
目的
本研究旨在评估与安慰剂和氯己定（CHX）漱口水相比，草药漱口水作为日常口腔卫生补充剂在治疗牙龈炎时对牙菌斑和炎症控制的总体效果。
方法
检索了PubMed、EMBASE、Cochrane系统评价数据库、Cochrane对照试验中心注册库和灰色文献数据库。仅纳入比较草药漱口水与安慰剂或CHX在牙龈炎患者日常口腔卫生中的随机对照试验（RCT），以比较不同漱口水对牙菌斑和炎症控制的效果。
结果
共有13项研究符合纳入标准，11项研究纳入荟萃分析。在牙菌斑和炎症相关指标方面，与安慰剂相比，草药漱口水有显著差异（奎格利-海因菌斑指数，QHPI：加权均数差 = -0.61，95%置信区间（-0.80，-0.42），<0.001；牙龈指数，GI：-0.28（-0.51，-0.06），=0.01；改良牙龈指数，MGI：-0.59（-1.08，-0.11），=0.02；牙龈出血指数，GBI：-0.06（-0.09，-0.04），<0.001）。草药漱口水与CHX漱口水之间未发现显著差异。
结论
作为牙龈炎患者日常口腔卫生的补充，草药漱口水在牙菌斑和炎症控制方面具有潜在益处。尽管在所选研究中未观察到草药漱口水与CHX漱口水之间的差异，但在向牙龈炎患者建议是否可以使用草药漱口水替代CHX漱口水之前，还需要进一步的高质量RCT提供更有力的支持（注册号：CRD42019122841）。
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