Wang Xuan, Jiang Xiaohui, Yu Liangmin
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, China.
Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
Biofouling. 2022 Jan;38(1):29-41. doi: 10.1080/08927014.2021.2010720. Epub 2021 Dec 7.
In this study, eight polyphenol derivatives were prepared to serve as green antifoulants. Polyphenol derivatives, which can hinder the growth of bacteria and algae and decrease the adhesion of some marine organisms, showed good AF activity; in particular, the activities of these derivatives were much higher than those of the corresponding polyphenols. The antibacterial rates of the products (20 μg ml) exceeded 88%. Moreover, the anti-algal rates of compounds a3, b1, b2, b3 and b4 (15 μg ml) were over 57% at 240 h, but these compounds showed low toxicity, and the 120 h EC values were > 6.60 μg ml. In addition, there were fewer marine microorganisms on the test panel than on the control. The above results show that some polyphenol derivatives possess relatively high antibacterial, anti-algal, and AF activity; more notably, the addition of chlorine atoms and amide groups can further increase the activity of these derivatives.
在本研究中，制备了八种多酚衍生物用作绿色防污剂。多酚衍生物能够阻碍细菌和藻类的生长，并降低一些海洋生物的附着力，表现出良好的防污活性；特别是，这些衍生物的活性远高于相应的多酚。产品（20μg/ml）的抗菌率超过88%。此外，化合物a3、b1、b2、b3和b4（15μg/ml）在240小时时的抑藻率超过57%，但这些化合物毒性较低，120小时的半数效应浓度值>6.60μg/ml。此外，测试面板上的海洋微生物比对照面板上的少。上述结果表明，一些多酚衍生物具有较高的抗菌、抑藻和防污活性；更值得注意的是，氯原子和酰胺基团的引入可进一步提高这些衍生物的活性。
