Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, 4450-208 Matosinhos, Portugal.
Mar Drugs. 2024 Jun 24;22(7):291. doi: 10.3390/md22070291.
Marine biofouling, caused by the deposition and accumulation of marine organisms on submerged surfaces, represents a huge concern for the maritime industries and also contributes to environmental pollution and health concerns. The most effective way to prevent this phenomenon is the use of biocide-based coatings which have proven to cause serious damage to marine ecosystems. Several research groups have focused on the search for new environmentally friendly antifoulants, including marine and terrestrial natural products and synthetic analogues. Some of these compounds have been incorporated into marine coatings and display interesting antifouling activities caused by the interference with the biofilm-forming species as well as by the inhibition of the settlement of macroorganisms. This review highlights the proof-of-concept studies of emerging natural or synthetic antifouling compounds in coatings, from lab-made to commercial ones, performed between 2019 and 2023 and their results in the field or in in vivo laboratorial tests.
海洋生物附着，是由海洋生物在水下表面的沉积和积累引起的，这对海洋产业来说是一个巨大的问题，也导致了环境污染和健康问题。防止这种现象最有效的方法是使用基于杀生物剂的涂料，但这些涂料已被证明会对海洋生态系统造成严重的破坏。一些研究小组专注于寻找新的环保型防污剂，包括海洋和陆地天然产物和合成类似物。其中一些化合物已被纳入海洋涂料中，并显示出有趣的防污活性，这是通过干扰生物膜形成物种以及抑制大型生物的定殖来实现的。本综述重点介绍了 2019 年至 2023 年间在涂料中使用新兴天然或合成防污化合物的概念验证研究，从实验室制造到商业应用，并介绍了它们在现场或体内实验室测试中的结果。
