Wang Xuan, Liu Zhenxia, Jiang Xiaohui, Yu Liangmin
Frontiers Science Center for Deep Ocean Multispheres and Earth System, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China.
Frontiers Science Center for Deep Ocean Multispheres and Earth System, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China; Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266100, China.
Mar Pollut Bull. 2022 Aug;181:113844. doi: 10.1016/j.marpolbul.2022.113844. Epub 2022 Jun 22.
In this study, N-hydroxymethylbenzamide was alkylated with various aromatic compounds to obtain five novel benzamide derivatives containing capsaicin (BDCC), and the BDCC were incorporated into coatings as auxiliary agents. The relationships between properties and structures were discussed based on experimental and theoretical results. The theoretical results showed the optimized configurations of BDCC and confirmed that the benzene ring, phenolic hydroxyl, ester and amide groups were active sites. Experimental results indicated that the antimicrobial and antifouling effects of compounds b1, b2 and b3 were better than those of chlorothalonil, their MIC and MBC values were no more than 64 and 512 μg·mL, and their test panels were covered only with small amounts of dirt and biofilms; they worked well as green antifouling additives. The experimental and theoretical results showed that BDCC and BDCC antifouling coatings were effective and eco-friendly.
在本研究中，N-羟甲基苯甲酰胺与各种芳香族化合物进行烷基化反应，得到了五种含辣椒素的新型苯甲酰胺衍生物（BDCC），并将BDCC作为助剂掺入涂料中。基于实验和理论结果讨论了性能与结构之间的关系。理论结果表明了BDCC的优化构型，并证实苯环、酚羟基、酯基和酰胺基是活性位点。实验结果表明，化合物b1、b2和b3的抗菌和防污效果优于百菌清，它们的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）值不超过64和512μg·mL，且测试板上仅覆盖少量污垢和生物膜；它们作为绿色防污添加剂效果良好。实验和理论结果表明，BDCC及其防污涂料是有效且环保的。
