Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
University of Chinese Academy of Sciences, Beijing, 10049, China.
Chem Rec. 2017 Dec;17(12):1213-1230. doi: 10.1002/tcr.201700019. Epub 2017 Jun 13.
A critical challenge in nanotechnology is the limited precision and controllability of the structural parameters, which brings about concerns in uniformity, reproducibility and performance. Self-assembled DNA nanostructures, as a newly emerged type of nano-biomaterials, possess low-nanometer precision, excellent programmability and addressability. They can precisely arrange various molecules and materials to form spatially ordered complex, resulting in unambiguous physical or chemical properties. Because of these, DNA nanostructures have shown great promise in numerous biomedical theranostic applications. In this account, we briefly review the history and advances on construction of DNA nanoarchitectures and superstructures with accurate structural parameters. We focus on recent progress in exploiting these DNA nanostructures as platforms for quantitative biosensing, intracellular diagnosis, imaging, and smart drug delivery. We also discuss key challenges in practical applications.
在纳米技术中，一个关键的挑战是结构参数的有限精度和可控性，这引起了人们对均匀性、可重复性和性能的关注。自组装 DNA 纳米结构作为一种新兴的纳米生物材料，具有低纳米精度、优异的可编程性和寻址能力。它们可以精确地排列各种分子和材料，形成空间有序的复合物，从而产生明确的物理或化学性质。由于这些特性，DNA 纳米结构在许多生物医学治疗应用中显示出巨大的潜力。在本综述中，我们简要回顾了具有精确结构参数的 DNA 纳米结构和超结构的构建历史和进展。我们重点介绍了最近利用这些 DNA 纳米结构作为定量生物传感、细胞内诊断、成像和智能药物输送平台的进展。我们还讨论了实际应用中的关键挑战。
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