Department of Integrative Medicine, Graduate School of Integrative Medicine, CHA University, 120 Haeryong-Ro, Kyeong-Gi, Pocheon, 11160, Republic of Korea.
Institute of Bioscience & Integrative Medicine, College of Korean Medicine, Daejeon Oriental Hospital of Daejeon University, Daedeok-Daero 176, Seo-Gu, Daejeon, 35235, Republic of Korea.
J Transl Med. 2021 Dec 7;19(1):502. doi: 10.1186/s12967-021-03170-0.
Chronic fatigue syndrome (CFS) is a long-term disabling illness accompanied by medically unexplained fatigue. This study aimed to explore the epidemiological characteristics of CFS in South Korea.
Using the nationwide medical records provided by the Korean Health Insurance Review & Assessment Service (HIRA), we analyzed the entire dataset for CFS patients diagnosed by physicians in South Korea from January 2010 to December 2020.
The annual mean incidence of CFS was estimated to be 44.71 ± 6.10 cases per 100,000 individuals [95% CI: 40.57, 48.76], and the prevalence rate was 57.70 ± 12.20 cases per 100,000 individuals [95% CI: 49.40, 65.79]. These two rates increased by 1.53- and 1.94-fold from 2010 to 2020, respectively, and showed an increasing trend with aging and an approximately 1.5-fold female predominance.
This study is the first to report the nationwide epidemiological features of CFS, which reflects the clinical reality of CFS diagnosis and care in South Korea. This study will be a valuable reference for studies of CFS in the future.
慢性疲劳综合征（CFS）是一种长期致残性疾病，伴有无法用医学解释的疲劳。本研究旨在探讨韩国 CFS 的流行病学特征。
使用韩国健康保险审查与评估服务（HIRA）提供的全国性医疗记录，我们分析了 2010 年 1 月至 2020 年 12 月期间韩国医生诊断的 CFS 患者的所有数据集。
CFS 的年平均发病率估计为每 10 万人 44.71±6.10 例[95%CI：40.57，48.76]，患病率为每 10 万人 57.70±12.20 例[95%CI：49.40，65.79]。这两个比率从 2010 年到 2020 年分别增加了 1.53 倍和 1.94 倍，并且随着年龄的增长呈上升趋势，女性比例约为男性的 1.5 倍。
这是首次报告韩国全国性 CFS 的流行病学特征，反映了韩国 CFS 诊断和护理的临床实际情况。本研究将为未来的 CFS 研究提供有价值的参考。
