中枢神经系统的白细胞介素-1由阿米巴样小胶质细胞产生。
Interleukin 1 of the central nervous system is produced by ameboid microglia.
作者信息
Giulian D, Baker T J, Shih L C, Lachman L B
出版信息
J Exp Med. 1986 Aug 1;164(2):594-604. doi: 10.1084/jem.164.2.594.
Abstract
By screening specific populations of rat brain cells, we found that ameboid microglia secrete an 18 kD peptide with IL-1 biological activity. The IL-1 activity released by microglia was found to be identical to rat macrophage IL-1 on fractionation by gel filtration and high pressure liquid anion-exchange chromatography, and it was neutralized by an antiserum specific for murine IL-1. When added to astroglia grown in culture, microglial IL-1 increased the cell number of five- to sevenfold, and increased astroglial incorporation of [3H]thymidine by three- to fivefold. We propose that the proliferation of astroglia in specific brain regions may be regulated by the signaled release of IL-1 from activated microglial cells.
摘要
通过筛选大鼠脑细胞的特定群体，我们发现阿米巴样小胶质细胞分泌一种具有IL-1生物活性的18 kD肽。在通过凝胶过滤和高压液相阴离子交换色谱法分级分离时，发现小胶质细胞释放的IL-1活性与大鼠巨噬细胞IL-1相同，并且它被针对小鼠IL-1的抗血清中和。当添加到培养的星形胶质细胞中时，小胶质细胞IL-1使细胞数量增加了五到七倍，并使星形胶质细胞对[3H]胸苷的掺入增加了三到五倍。我们提出，特定脑区星形胶质细胞的增殖可能受活化小胶质细胞释放的IL-1信号调节。
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