Department of Biological Sciences, California State Polytechnic University, Pomona, California, USA.
Exp Physiol. 2023 Jul;108(7):917-924. doi: 10.1113/EP090780. Epub 2023 Apr 9.
What is the topic of this review? This review focuses on the physiological role of the cytokine interleukin-1β in the CNS. What advances does it highlight? Traditionally, interleukin-1β is known as a key mediator of inflammation and immunity. This review highlights the more recent findings describing how interleukin-1β signalling is required to maintain homeostasis in the CNS.
Since its discovery in the early 1940s, the interleukin-1 (IL-1) cytokine family has been associated primarily with acute and chronic inflammation. The family member IL-1β is produced by different leucocytes, endothelial cells and epithelial cells. This cytokine has been characterized as a key modulator of inflammation and innate immunity because it induces the transcription of several downstream inflammatory genes. More recently, several groups have demonstrated that IL-1β production is also required to maintain homeostasis in several organ systems. This review focuses on providing an overview of the more recently characterized role of IL-1β in the physiology of the CNS. So far, IL-1β signalling has been implicated in neuronal survival, neurite growth, synaptic pruning, synaptic transmission, neuroplasticity and neuroendocrine functions.
这篇综述的主题是什么？本综述重点介绍了细胞因子白细胞介素-1β（interleukin-1β）在中枢神经系统中的生理作用。它强调了哪些进展？传统上，白细胞介素-1β被认为是炎症和免疫的关键介质。本综述强调了最近的发现，即描述白细胞介素-1β信号如何维持中枢神经系统的内稳态。
自 20 世纪 40 年代初发现以来，白细胞介素-1（IL-1）细胞因子家族主要与急性和慢性炎症有关。细胞因子白细胞介素-1β由不同的白细胞、内皮细胞和上皮细胞产生。这种细胞因子被认为是炎症和先天免疫的关键调节剂，因为它诱导了几个下游炎症基因的转录。最近，有几个研究小组表明，白细胞介素-1β的产生对于维持几个器官系统的内稳态也是必需的。本综述重点介绍了白细胞介素-1β在中枢神经系统生理学中最近被描述的作用。到目前为止，白细胞介素-1β信号已被牵涉到神经元存活、神经突生长、突触修剪、突触传递、神经可塑性和神经内分泌功能。
