Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Attar-neishabouri Ave, Golgasht St, 5165665931, Tabriz, Iran.
BMC Res Notes. 2021 Dec 7;14(1):443. doi: 10.1186/s13104-021-05857-5.
Evidence show that cocaine and amphetamine regulated transcript-prepropeptide (CART-PT) gene variants may affect obesity related traits, but little is known about its end points. In the current study, we aimed to evaluate the interaction of CARTPT gene polymorphism with diet quality indices including dietary approaches to stop hypertension (DASH) and Mediterranean diet score (MDS) on cardio-metabolic risk factors. This cross sectional study recruited 288 apparently healthy obese individuals. Diet quality indices including DASH and MDS were evaluated using semi quantitative food frequency questionnaire (FFQ). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for CARTPT genotypes.
No significant differences was reported for general characteristics and biochemical parameters across genotypes except for QUICKI among females (P = 0.01) and it was higher in heterozygous genotype. There was significant CARTPT-DASH interactions affecting serum fasting glucose level (P = 0.049). However, in relation to CERTPT-MDS interactions, the highest level of insulin (P = 0.003) and HOMA-IR (P = 0.003) values were shown among AA carriers in high adherence to MDS, while AA carriers in high compliance to MDS experienced decreased level of QUICKI (P = 0.001).
有证据表明可卡因和安非他命调节转录前肽（CART-PT）基因变异可能影响与肥胖相关的特征，但对其终点知之甚少。在本研究中，我们旨在评估 CART-PT 基因多态性与饮食质量指数（包括停止高血压的饮食方法（DASH）和地中海饮食评分（MDS））之间的相互作用对心脏代谢危险因素的影响。这项横断面研究招募了 288 名明显健康的肥胖个体。使用半定量食物频率问卷（FFQ）评估饮食质量指数，包括 DASH 和 MDS。使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测 CART-PT 基因型。
除了女性 QUICKI （P = 0.01）在杂合基因型中较高外，基因型之间的一般特征和生化参数没有显著差异。存在显著的 CART-PT-DASH 相互作用影响血清空腹血糖水平（P = 0.049）。然而，关于 CERTPT-MDS 相互作用，在 MDS 高度依从性的 AA 携带者中，胰岛素（P = 0.003）和 HOMA-IR（P = 0.003）的最高水平显示，而 MDS 高度依从性的 AA 携带者 QUICKI 水平降低（P = 0.001）。
