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早期分娩及其与普遍二孩政策的关联:中国的一项全国性横断面研究。

Early-term birth and its association with universal two-child policy: a national cross-sectional study in China.

机构信息

Department of Women and Children's Health Care, School of Medicine,Tongji University, Shanghai, China.

Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine,Tongji University, Shanghai, China.

出版信息

BMJ Open. 2021 Dec 7;11(12):e054959. doi: 10.1136/bmjopen-2021-054959.

Abstract

OBJECTIVE

To describe the epidemiology of early-term birth (ETB) at the national level in China, and explore the association and mediating factors between ETB and policy between universal two-child policy and ETB, so as to explain the potential reason for such a relationship and provide evidence for future ETB interventions in the era of the new birth control policy.

DESIGN

Cross-sectional study.

PARTICIPANTS

The cross-sectional study used data from China Labour and Delivery Survey between 2015 and 2016. A total of 75 132 survey data collected from 89 hospitals in 25 provinces were included in the analysis. We further explored the association between the universal two-child policy and ETB.

RESULTS

The weighted incidence of ETB was 30.1 per 100 all births (95% CI 30.06% to 30.14%) or 29.88 per 100 live births (95% CI 29.97% to 30.05%) between 2015 and 2016 in China. There was an association between the universal two-child policy and ETB (relative risk, RR 1.19, 95% CI 1.15 to 1.23), which was not mediated by maternal age (RR 1.17, 95% CI 1.13 to 1.22), previous uterine scars (RR 1.18, 95% CI 1.14 to 1.22), parity (RR 1.19, 95% CI 1.15 to 1.24) and other measured conditions (each p<0.05). Stratified analysis showed that the association between universal two-child policy and ETB were the strongest in multiparous young women or women without previous uterine scars (each p<0.05), and disappeared in all women of advanced maternal age (each p>0.05).

CONCLUSION

The incidence of ETB was high in China when compared with most of reported countries, and there might be a link between two-child policy and ETB. Obstetric practice such as selective induced labour and caesarean section should be revised with ETB risks in mind, when ETB is more likely to happen under the universal two-child policy. Preventing ETB should not be neglected in multiparous young women or those without previous uterine scars under the new policy.

摘要

目的

描述中国国家级早期早产(ETB)的流行病学,并探讨普遍二孩政策与 ETB 之间的关联和中介因素,以解释这种关系的潜在原因,并为新生育政策时代未来 ETB 的干预措施提供依据。

设计

横断面研究。

参与者

本横断面研究使用了 2015 年至 2016 年中国分娩调查的数据。共纳入了来自全国 25 个省份 89 家医院的 75132 例调查数据进行分析。我们进一步探讨了普遍二孩政策与 ETB 之间的关联。

结果

2015 年至 2016 年中国 ETB 的加权发生率为每 100 例活产中 30.1 例(95%CI 30.06%至 30.14%)或每 100 例活产中 29.88 例(95%CI 29.97%至 30.05%)。普遍二孩政策与 ETB 之间存在关联(相对风险 RR 1.19,95%CI 1.15 至 1.23),这种关联不受产妇年龄(RR 1.17,95%CI 1.13 至 1.22)、既往子宫瘢痕(RR 1.18,95%CI 1.14 至 1.22)、经产(RR 1.19,95%CI 1.15 至 1.24)和其他测量条件(均 p<0.05)的影响。分层分析表明,在多产妇的年轻妇女或没有既往子宫瘢痕的妇女中,普遍二孩政策与 ETB 之间的关联最强(均 p<0.05),而在所有高龄产妇中,这种关联消失(均 p>0.05)。

结论

与大多数报告的国家相比,中国 ETB 的发生率较高,二孩政策与 ETB 之间可能存在联系。在普遍二孩政策下,ETB 更有可能发生,因此应考虑 ETB 风险,对选择性引产和剖宫产等产科实践进行修订。在新政策下,应注意预防多产妇的年轻妇女或没有既往子宫瘢痕的妇女发生 ETB。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bf4/8655521/f1b077f96dd1/bmjopen-2021-054959f01.jpg

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